2022
DOI: 10.1016/j.ica.2022.121184
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Synthesis of dual-functional pyrazole-based transition metal complexes for improved urease and nitrification activities

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Cited by 8 publications
(10 citation statements)
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“…More importantly, the comparisons of urease inhibition of the Cu-CP-1 composites with other reported metal–organic materials for urease inhibition are listed in Table S5 (ESI†). As a comparison, typical acetohydroxamic acid (AHA), 15 metal–organic salt (MOS), 6 and mononuclear Cu-based complexes 7,30,31 were further used as reference UIs. It was found that the IC 50 value of Cu-CP-1 was significantly lower than that of other UIs, demonstrating the efficient inhibition of urease by Cu-CP-1 with high biological activity and potency, which might generate considerable effects at low doses.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…More importantly, the comparisons of urease inhibition of the Cu-CP-1 composites with other reported metal–organic materials for urease inhibition are listed in Table S5 (ESI†). As a comparison, typical acetohydroxamic acid (AHA), 15 metal–organic salt (MOS), 6 and mononuclear Cu-based complexes 7,30,31 were further used as reference UIs. It was found that the IC 50 value of Cu-CP-1 was significantly lower than that of other UIs, demonstrating the efficient inhibition of urease by Cu-CP-1 with high biological activity and potency, which might generate considerable effects at low doses.…”
Section: Resultsmentioning
confidence: 99%
“…Nitrogen-containing heterocyclic organic compounds, 6,7 such as aminopyrimidine 6 or five-membered heterocyclic compounds, 7 have been widely used in the study of the inhibition of urease activity. Molecular docking shows that these heterocyclic structures can enter the active center of urease and interact with the nearby amino acid residues.…”
Section: Introductionmentioning
confidence: 99%
“…32 Based on the above comparison, MOS 1 has a stronger activity than the metal salt, ligands and other MOSs, which may be attributed to Cu 2+ with higher urease inhibitory activity and its N-donor ligand with a synergistic effect. 33…”
Section: Resultsmentioning
confidence: 99%
“…32 Based on the above comparison, MOS 1 has a stronger activity than the metal salt, ligands and other MOSs, which may be attributed to Cu 2+ with higher urease inhibitory activity and its N-donor ligand with a synergistic effect. 33 Furthermore, the time course of inhibition of jack bean urease activity by different concentrations of MOS 1 was further studied. In the concentration range of 0.625-10 μM with the time of 0 to 7 h, the inhibition rate increases with the increase of the concentration of the MOS 1 solution (Fig.…”
Section: Dalton Transactions Papermentioning
confidence: 99%
“…3d, the inhibition rate of Cu-CP-2 decreased smoothly with increasing the incubation time. The incubation time was increased from 1 h to 7 h. At 0.3 µM Cu-CP-2 concentration, the urease inhibition rate was 16% when the incubation time was 3 h. The semi-inhibitory concentration IC 50 values of Cu-CP-1 and Cu-CP-2 were calculated to be 0.53 ± 0.01 µM and 1.44 ± 0.01 µM, 44 respectively, as shown in Table 1. By comparison, it was found that the IC 50 of Cu-CPs as UIs was significantly lower than that of other inhibitors, which demon-…”
Section: Inhibitory Activity Against Ureasementioning
confidence: 99%