Synthesis of Ferrocene Based Organometallic Compounds & Antimicrobial Activity

Abstract

The synthesis, characterisation, spectral studies, antibacterial and fugal studies of some transition metal ions like Mn ++ , Co ++ , Ni ++ , Cu ++ , Pd ++ and Pt ++ complexes of ferrocene based Organometallic compounds have been reported. The coordinate bonding of nitrogen to the central metal atom which reduces the electron density in the both azomethine link and thus lower the-HC=Nabsorption. The elemental analysis data exhibit the formation of 1:1 [M: L] ratio with coordination number six in the all complexes. The complexes have with octahedral geometry and D 4 h symmetry. The ferrocene based organometallic compound shows a molecular ion peak at m/z 482.4 which is equal to theoretical molecular weight. The molar conductance value indicates that, they are non-electrolytic in nature. These complexes were tested with some bacteria and fungi.

Contemporary Developments in Ferrocene Chemistry: Physical, Chemical, Biological and Industrial Aspects

“…Ahmad et al carried out the synthesis of four newly modified Mannich bases of Lawsone that accommodated the Ferrocene units. Lawsone contains a naphthoquinone nucleus whose drug properties were already reported [132]. The biological study showed that compound 124a is the most active member among a series of four compounds that had maximum antiproliferative activity and it could be a promising lead for the development of ligands that could be used for the treatment of hormone-refractory prostate carcinomas and MDR tumors (Figure 48).…”

“…Nowadays, ferrocene derivatives have found their way into pharmacology as potent HIV, anti-cancer, anti-trypanosomal, antimalarial, anti-diabetic, and antiviral agents, among others. These potent ferrocenebased drugs were either prepared through organic synthesis or developed from alreadyrecommended drugs via drug reprofiling or repurposing strategies in which the structural variation of established drugs with ferrocene scaffolds was reported [131,132].…”