Synthesis of ferrocenyl pyrazoles by the reaction of 3-ferrocenylpropynal with hydrazinium salts

Synthesis, spectral characterization and electrochemical properties of 1H-3-(o-, m- and p-ferrocenylphenyl)-1-phenylpyrazole-4-carboxaldehydes

“…Although the pyrazole motif makes up the core structure of numerous biologically active compounds [16], it did not prompt chemists to put intensive efforts into synthesis of ferrocene derivatives of pyrazole. Thus, only a limited number of publications have been devoted to this problem until present [17,18]. We recently reported the synthesis of 1H-3-ferrocenyl-1-phenylpyrazole-4-carboxaldehyde (Scheme 1; R 1 = phenyl, R 2 = ferrocenyl) [19] by the literature method [20] used in the synthesis of the corresponding non-ferrocene derivatives (Scheme 1, R 1 , R 2 = alkyl or aryl).…”

Synthesis, single-crystal characterization and preliminary biological evaluation of novel ferrocenyl pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives

“…The dihedral angle between the substituted Cp ring (C1-C5) and the pyrazole ring (N1/N2/C11/C12/C13) of 12.0(2) in 6f and 13.1 (2) in 6g are in the range of that of the ferrocenyl-substituted pyrazole (8.20 w 45.36 ) [27,31,32]. The C1-C11 distance 1.459(4) Å of 6g is slightly shorter than that of 6f (1.467(4) Å).…”

Synthesis, Crystal Structure and Thermal Properties of N-Acetyl-3-(2-furyl)-5-ferrocenyl-2-pyrazoline and N-Acetyl-3-(2-thienyl)-5-ferrocenyl-2-pyrazoline

“…Recent studies have shown that the combination of biological active N-heterocyclic compounds such as pyrazolines and pyrazoles with ferrocene moiety can result in favorable change of biological properties [29][30][31][32][33][34] which is rationalized as being due to their different membrane-permeation properties and anomalous metabolism [35][36][37][38]. As mentioned earlier, although 2-pyrazolines are amongst the most intensely studied compounds; N-acetylated ferrocenyl-2-pyrazoline derivatives are relatively less explored [29,32].…”

“…As mentioned earlier, although 2-pyrazolines are amongst the most intensely studied compounds; N-acetylated ferrocenyl-2-pyrazoline derivatives are relatively less explored [29,32].…”