Synthesis of flavone-8-carboxylic acid analogues as potential antitumor agents

Cutler, SJ; El-Kabbani, F. M.; Keane, Charlene; Fisher-Shore, SL; McCabe, Francis L.; Johnson, Richard K.; Blanton, C. DeWitt

doi:10.1016/0223-5234(93)90127-z

Cited by 11 publications

(1 citation statement)

References 25 publications

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“…In contrast, only few works focus on flavone with carboxyl group. For example, Cutler et al synthesized a series of substituted flavone-8-carboxylic acids, some of which showed solid tumor inhibition effect in mice bearing B16F10 melanomas [17]. Additionally, then, Zwaagstra et al…”

Section: Introductionmentioning

confidence: 99%

The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid

et al. 2022

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A novel two-dimensional copper(II) framework (LDU-1), formulated as {[Cu2(L)2·2NMP}n (H2L = flavone-6,2′-dicarboxylic acid, NMP = N-Methyl pyrrolidone), has been constructed under solvothermal conditions and characterized by single-crystal X-ray diffraction, infrared spectroscopy (IR), thermogravimetric analysis and powder X-ray diffraction (PXRD). In the crystal structure, the Cu(II) shows hex-coordinated with the classical Cu paddle-wheel coordination geometry, and the flavonoid ligand coordinates with the Cu(II) ion in a bidentate bridging mode. Of particular interest of LDU-1 is the presence of anti-tumor activity against three human cancer cell lines including lung adenocarcinoma(A549), Michigan cancer foundation-7 (MCF-7), erythroleukemia (K562) and murine melanoma B16F10, indicating synergistic enhancement effects between metal ions and organic linkers. A cell cycle assay indicates that LDU-1 induces cells to arrest at S phase obviously at a lower concentration.

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Section: Introductionmentioning

confidence: 99%

The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid

et al. 2022

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Synthesis and Antitumour Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 31): 2-Heteroaryl Derivatives

Aitken

Bibby

Double

et al. 1998

Arch. Pharm. Pharm. Med. Chem.

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A range of 14 derivatives of flavone‐8‐acetic acid (FAA) with a heterocyclic substituent in place of the 2‐phenyl group have been prepared and their anti‐tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. Some of the compounds, notably 2c, d and s, showed significant in vivo activity and these require further studies in order to evaluate their potential for development.

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Synthesis and Antitumour Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 41) : Variation of the Basic Structure

Aitken

Bibby

Cooper

et al. 2000

Arch. Pharm. Pharm. Med. Chem.

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Synthesis of flavone-8-carboxylic acid analogues as potential antitumor agents

Cited by 11 publications

References 25 publications

The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid

The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid

Synthesis and Antitumour Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 31): 2-Heteroaryl Derivatives

Synthesis and Antitumour Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 41) : Variation of the Basic Structure

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