Synthesis of Flavonoids

Wagner, Hildebert; Farkas, L.

doi:10.1007/978-1-4899-2909-9_4

Cited by 36 publications

(16 citation statements)

References 233 publications

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“…The chalcones (7, 11) and #avanones (13, 15) were obtained from natural products (Pederiva et al, 1985). Chalcones 1}6, and 8}10 were synthesized using the Claisen}Schmidt reaction (Wagner & Farkas, 1975), and #avanones (12, 14) by means of traditional methods (Geissman & Clinton, 1946). Compounds 16}18 were purchased from Sigma Chemical Co. …”

Section: Analysed Flavonoidsmentioning

confidence: 99%

Antibacterial Activity of Flavonoids Against Methicillin-resistant Staphylococcus aureus strains

Alcaráz

Blanco

Puig

et al. 2000

Journal of Theoretical Biology

204

113

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Section: Analysed Flavonoidsmentioning

confidence: 99%

Antibacterial Activity of Flavonoids Against Methicillin-resistant Staphylococcus aureus strains

Alcaráz

Blanco

Puig

et al. 2000

Journal of Theoretical Biology

204

113

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“…These synthetic approaches use mainly chemicals such as acetic acid, chalones, flavonones, acid chloride and cinnamic acid as starting materials. They have been described in detail by Dhar (10), Heller and Forkmann (14), and Wagner and Farkas (44).…”

Section: Sourcesmentioning

confidence: 99%

“…Huang et al (19) followed the traditional methods and procedures mentioned above (10,14,44) to synthesize wogonin and found that the yield was low (below 10%). They later developed a new laboratory method to synthesize wogonin with a 24% yield.…”

Section: Sourcesmentioning

confidence: 99%

Therapeutic Potential of Wogonin: A Naturally Occurring Flavonoid

et al. 2005

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The search for flavonoids with novel therapeutic effects has been intense. Wogonin, as a naturally existing monoflavonoid, has been shown to have therapeutic potential in vitro and in vivo. Methods for its extraction from herbs and its chemical synthesis have been developed. Pharmacokinetic studies have shown a rapid tissue distribution and prolonged plasma elimination phase of wogonin. It has been shown experimentally that wogonin exerts anti-oxidant activity, which may, in part, underlie its antiinflammatory, anti-cancer, antiviral and neuroprotective actions. The recent discovery of its anxiolytic activity suggests a new mechanism of action, involving interaction with the benzodiazepine (BZD) binding site of the GABA A receptor and modulation of this receptor activity. Although the safety record of wogonin is remarkable and voluminous literature about its pharmacological effects is available, it has not been used in Western medicine in the form of a pure chemical. In this article we review its therapeutic effects, its sources and pharmacokinetic profile to highlight its therapeutic potential.

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“…On the other hand resveratrol is of much more restricted food distribution [14]. If necessary, a previous review on this subject can be consulted [23]. The metabolism, the bioavailability and the bioefficacy of dietary phenols have been extensively studied during the last decade [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

(Bio)chemical Labelling Tools for Studying Absorption & Metabolism of Dietary Phenols - An Overview

2012

COC

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This review covers recent advances in the synthetic labelling and biolabelling of dietary polyphenols over the last 10 years. During this period, the production of labelled flavans and their proanthocyanidin oligomers, isoflavones, lignans and stilbenes such as resveratrol, has received the most attention. Radiolabelled compounds are mostly used for tissue distribution and pharmacokinetic studies in animals. In parallel, methods for the synthesis of more easily handled compounds labelled with stable isotopes have been extensively developed. The use of both types of labelled compounds in metabolic studies has significantly contributed to the identification of metabolites produced by the intestine, the liver, and/or the colonic microflora.

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Synthesis of Flavonoids

Cited by 36 publications

References 233 publications

Antibacterial Activity of Flavonoids Against Methicillin-resistant Staphylococcus aureus strains

Antibacterial Activity of Flavonoids Against Methicillin-resistant Staphylococcus aureus strains

Therapeutic Potential of Wogonin: A Naturally Occurring Flavonoid

(Bio)chemical Labelling Tools for Studying Absorption & Metabolism of Dietary Phenols - An Overview

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