Synthesis of flexirubin-mediated silver nanoparticles using Chryseobacterium artocarpi CECT 8497 and investigation of its anticancer activity

Venil, Chidambaram Kulandaisamy; Sathishkumar, Palanivel; Malathi, M.; Usha, R.; Jayakumar, R.; Yusoff, Abdull Rahim Mohd; Ahmad, Wan Azlina

doi:10.1016/j.msec.2015.10.019

Cited by 56 publications

(19 citation statements)

References 25 publications

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“…290 Venil et al reported flexirubin (a bacterial pigment)-mediated silver nanoparticles for the first time that were highly cytotoxic (IC 50 value of 36 μg/mL) against human breast cancer cell lines (MCF-7). 291 Nowadays, chitosan-based biosynthesized silver nanoparticles are mostly synthesized and used against different cancer cell lines. A study performed by Venkatesan et al demonstrated that porous chitosan-alginate-biosynthesized AgNPs exhibited cytotoxic effects against breast cancer cell line MDA-MB-231 (IC 50 =4.6 mg).…”

Section: Anticancer Property Of Agnpsmentioning

confidence: 99%

Nanosilver: new ageless and versatile biomedical therapeutic scaffold

Khan¹,

Saleh²,

Wahab³

et al. 2018

IJN

170

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Silver nanotechnology has received tremendous attention in recent years, owing to its wide range of applications in various fields and its intrinsic therapeutic properties. In this review, an attempt is made to critically evaluate the chemical, physical, and biological synthesis of silver nanoparticles (AgNPs) as well as their efficacy in the field of theranostics including microbiology and parasitology. Moreover, an outlook is also provided regarding the performance of AgNPs against different biological systems such as bacteria, fungi, viruses, and parasites (leishmanial and malarial parasites) in curing certain fatal human diseases, with a special focus on cancer. The mechanism of action of AgNPs in different biological systems still remains enigmatic. Here, due to limited available literature, we only focused on AgNPs mechanism in biological systems including human (wound healing and apoptosis), bacteria, and viruses which may open new windows for future research to ensure the versatile application of AgNPs in cosmetics, electronics, and medical fields.

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Section: Anticancer Property Of Agnpsmentioning

confidence: 99%

Nanosilver: new ageless and versatile biomedical therapeutic scaffold

Khan¹,

Saleh²,

Wahab³

et al. 2018

IJN

170

View full text Add to dashboard Cite

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“…Cytochrome is involved in the bacterial synthesis of NPs. Thus, the pigment Chryseobacterium artocarpi CECT 8497 is used to create coexisting spherical Ag-NPs (Venil et al, 2016). Biosynthesis of extracellular Cu-NPs from Shewanella loihica PV-4 as electron donors for Cu 2+ used cytoplasmic components such as NADH/NADPH, vitamins and organic acids.…”

Section: Fig 2 General Scheme Of Synthesis Of Nanoparticles Of Metamentioning

confidence: 99%

Bacterial synthesis of nanoparticles: A green approach

et al. 2020

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In recent decades, the attention of scientists has been drawn towards nanoparticles (NPs) of metals and metalloids. Traditional methods for the manufacturing of NPs are now being extensively studied. However, disadvantages such as the use of toxic agents and high energy consumption associated with chemical and physical processes impede their continued use in various fields. In this article, we analyse the relevance of the use of living systems and their components for the development of "green" synthesis of nano-objects with exceptional properties and a wide range of applications. The use of nano-biotechnological methods for the synthesis of nanoparticles has the potential of large-scale application and high commercial potential. Bacteria are an extremely convenient target for green nanoparticle synthesis due to their variety and ability to adapt to different environmental conditions. Synthesis of nanoparticles by microorganisms can occur both intracellularly and extracellularly. It is known that individual bacteria are able to bind and concentrate dissolved metal ions and metalloids, thereby detoxifying their environment. There are various bacteria cellular components such as enzymes, proteins, peptides, pigments, which are involved in the formation of nanoparticles. Bio-intensive manufacturing of NPs is environmentally friendly and inexpensive and requires low energy consumption. Some biosynthetic NPs are used as heterogeneous catalysts for environmental restoration, exhibiting higher catalytic efficiency due to their stability and increased biocompatibility. Bacteria used as nanofactories can provide a new approach to the removal of metal or metalloid ions and the production of materials with unique properties. Although a wide range of NPs have been biosynthetic and their synthetic mechanisms have been proposed, some of these mechanisms are not known in detail. This review focuses on the synthesis and catalytic applications of NPs obtained using bacteria. Known mechanisms of bioreduction and prospects for the development of NPs for catalytic applications are discussed.

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“…Flexirubin mediated silver nanoparticles synthesised from Chyrseobacterium artocarpi CECT 8497 showed anticancer activity against human breast cancer cells, MCF-7 with a low IC 50 value of 36 mg/mL via apoptosis. Combination of silver and flexirubin as nanoparticles exert synergistic cytotoxic effect on cancer cells by entering into the cells or nucleus and causing higher cell death (Venil et al, 2016a). Prashanti et al (2015) employed various approaches to study anticancer activity of yellow pigment produced by Streptomyces griseoaurantiacus JUAC T01 against cervical cancer (HeLa) and liver cancer (HepG2) cells.…”

Section: Anti-tumoral Activitiesmentioning

confidence: 99%

“…The research concerning flexirubin has mainly focused on isolation of pigment producing microorganism and optimisation of pigment production. In addition to its biological activity as antioxidant activity, flexirubin has also exhibit anticancer activity in human breast cancer (Venil et al, 2016a(Venil et al, , 2016b.…”

Section: Potential Industrial Applications Of Yellowish-orange Pigmentsmentioning

confidence: 99%

Current perspective of yellowish-orange pigments from microorganisms- a review

Aruldass

Dufossé²,

Ahmad

2018

Journal of Cleaner Production

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Natural yellowish-orange pigments are derived from bacteria, yeasts, fungi and microalgae, including Chryseobacterium, Monascus and Chlorella. The purpose of this review is to provide an overview of these pigments in various aspects towards exploiting them for numerous functions. These pigments are produced in various shades of yellow-orange and categorised as carotenoids, anthraquinones, zeaxanthin, flexirubin and other compounds. They served as alternative colourants to replace hazardous and toxic synthetic pigments. Researchers are in progress to increase the pigment yield by improving the strains genetically, optimising the fermentation process and utilising cheap agroindustrial waste to reduce the production cost. Yellowish-orange pigments are applied in food, pharmaceuticals, cosmetics and textile industries. This review summarises the current technology status and challenges, economics, biosyn-thesis of pigment, novel strategies for production of yellowish-orange pigments, biological properties of pigments and metabolic engineering of microorganism with a focus on applications of pigments in food, pharmaceutical, dyeing industries as well as on other applications.

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Synthesis of flexirubin-mediated silver nanoparticles using Chryseobacterium artocarpi CECT 8497 and investigation of its anticancer activity

Cited by 56 publications

References 25 publications

Nanosilver: new ageless and versatile biomedical therapeutic scaffold

Nanosilver: new ageless and versatile biomedical therapeutic scaffold

Bacterial synthesis of nanoparticles: A green approach

Current perspective of yellowish-orange pigments from microorganisms- a review

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