Synthesis of fluorescent drug molecules for competitive binding assay based on molecularly imprinted polymers

Abstract

Drug molecules (metronidazole, zidovudine and lamivudine) were successfully labelled with a fluorescent reagent and used to develop fluorescent biomimetic immunosorbent assays using molecularly imprinted polymers in the place of natural antibody.

Comprehensive investigation of succinic acid production by Actinobacillus succinogenes: a promising native succinic acid producer

“…2,3 In the pharmaceutical industry, succinic acid acts as a natural prodrug. 4,5 In the agricultural field, succinic acid is a well-known growth regulator, which can be used for seed treatment and plant rooting. 6 In the food industry, succinic acid can be used as a flavoring enhancer in beverages, a bread-softening agent, and a catalyst for food seasoning preparation.…”

“Monoclonal-type” plastic antibodies for SARS-CoV-2 based on Molecularly Imprinted Polymers

“…Plastic antibodies made from tailor-made polymeric imprinted nanoparticles represent an alternative to the traditional antibodies, which require an expensive production procedure and are often unreliable due to their restricted stability (Refaat et al, 2019;Xu et al, 2019). Being synthetic 6 materials, MIPs are robust, physically and chemically stable in a wide range of conditions, including temperature and pH, and more easily available due to a low-cost, reproducible and relatively fast and easy preparation compared to the biological counterpart (Piloto et al, 2018;Wubulikasimu et al, 2019). Therefore, this kind of materials combines the robustness of polymers with the selectivity of natural receptors (Capriotti et al, 2020) and could find applications in several fields, including separation, catalysis and drug delivery, as sensors, synthetic biomimetic receptors and recognition elements in bioanalytical assays (Pan et al, 2018).…”

Exploring the fluorescence properties of tellurium-containing molecules and their advanced applications

“…Their prowess extends to investigating molecular interactions, [15][16][17] decoding cellular processes, [18][19][20] and identifying crucial biomarkers. [21][22][23][24] Their significance extends to healthcare, where they play a crucial role in disease diagnosis, [25][26][27] pharmaceutical development, 28,29 and cutting-edge imaging methods, [30][31][32] thus propelling the frontier of medical understanding and technology.…”