Synthesis of fluorinated spiro-1,3-oxazines and thiazines via Selectfluor-mediated intramolecular cyclization

Abstract

A fluorination-induced intramolecular cyclization for the synthesis of fluoro-substituted spiro-1,3-oxazine and spiro-1,3-thiazine derivative is described. N-(2-(cyclohex-1-en-1-yl)ethyl)benzamide and benzothioamide are used as the substrate, and the cationic fluorinating agent Selectfluor works...