Synthesis of Fluorine‐Containing C2‐Tetrasubstituted Indolin–3‐ones via Rapid Incorporation of Difluoroacetate Radical Into 2‐Aryl‐3H‐indol‐3‐ones

Abstract

Here, we have successfully achieved the addition of difluoroacetate radicals to 2‐aryl‐3H‐indol‐3‐ones, enabling various difluoroalkylations of C2‐tetrasubstituted 2‐aryl indolin‐3‐ones in a highly efficient and economical manner. It is worth mentioning that these difluoroalkylation compounds can be easily transformed into various derivatives under mild reaction conditions. Control experiments suggest the involvement of ethyl difluoroacetate radical species in the reaction.