Synthesis of folic acid loaded g-C3N4/Ag2S nanohybrids for near infrared light mediated photothermal ablation of breast cancer cells

Alomari, Reem A.; Athinarayanan, Jegan; Periasamy, Vaiyapuri Subbarayan; Al-Harbi, Laila Naif; Alshatwi, Ali A.

doi:10.1016/j.diamond.2023.109785

Cited by 6 publications

(3 citation statements)

References 43 publications

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“…31 A mild or vigorous NIR irradiation applied in PTT generates heat between 43-55 • C and 55-100 • C, resulting in rapid cell death through denaturation of proteins and destruction of cell membranes. 31,49,50 According to these results, the dispersion temperature of MNs increases with NIR exposure time and in a concentration-dependent manner. These results are consistent with earlier reports.…”

Section: Resultsmentioning

confidence: 93%

“…Earlier studies demonstrated that PTT uses NIR irradiation to increase local temperature and cause regional photocoagulation 31 . A mild or vigorous NIR irradiation applied in PTT generates heat between 43–55°C and 55–100°C, resulting in rapid cell death through denaturation of proteins and destruction of cell membranes 31,49,50 . According to these results, the dispersion temperature of MNs increases with NIR exposure time and in a concentration‐dependent manner.…”

Section: Resultsmentioning

confidence: 97%

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Mucilage‐assisted fabrication of molybdenum trioxide nanostructures for photothermal ablation of breast cancer cells

Alomari,

Athinarayanan,

Periasamy

et al. 2023

Biotech and App Biochem

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Nanostructures have been used for various biomedical applications due to their optical, antibacterial, magnetic, antioxidant, and biocompatible properties. Cancer is a prevalent disease that severely threatens human life and health. Thus, innovative and effective therapeutic approaches are urgently required for cancer. Photothermal therapy (PTT) is a promising approach to killing cancer cells. In this investigation, we developed a low‐cost, simple, green technique to fabricate molybdenum trioxide nanostructures (MNs) using Opuntia ficus‐indica mucilage as a template. Moreover, the MNs were functionalized with folic acid (FA) for cancer PTT. The X‐ray diffractometer results revealed that the prepared MNs have an orthorhombic crystal phase. The transmission electron microscope image of MNs shows a flake shape with 20–150 nm diameter. The cytotoxicity of MNs and FA‐conjugated MNs was studied in vitro. These cell viability assay results suggested that fabricated MoO3 nanostructures reduced 25% of cell viability in MCF‐7 cells, even at high doses. However, even with high‐dose treatment, FA/MNs do not cause significant cell death. Acridine orange/ethidium bromide (AO/EB) staining revealed DNA and chromatin condensation in MCF‐7 cells exposed to MNs. Overall, the in vitro study results suggested that FA/MNs have excellent biocompatibility, which applies to biomedical applications. MNs dispersion temperature gradually increases from 26 to 58°C under 808 nm laser irradiation. We found significant mortality rates after NIR irradiation in MNs‐ or FA/MNs‐treated MCF‐7 cells. These findings suggest that FA/MNs can be used as an effective photothermal agent to treat breast cancer.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 97%

Mucilage‐assisted fabrication of molybdenum trioxide nanostructures for photothermal ablation of breast cancer cells

Alomari,

Athinarayanan,

Periasamy

et al. 2023

Biotech and App Biochem

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“…Determination of Mitochondrial Membrane Potential Loss: An essential sign of mitochondrial health was mitochondrial membrane potential (MMP). [43,44] By staining with JC-1, the study had examined the role of WSMC-NMs and MSMC-NMs on MMP. In 24-well plates, about 40 000 cells were added per well and left to incubate.…”

Section: Characterization Of Starch-myristic Acid Complexmentioning

confidence: 99%

Morphological, Thermal, and Cytotoxicity Features Assessment of Starch–Myristic Acid Complex‐Derived Nanostructured Materials

Almushawah,

Periasamy,

Athinarayanan

et al. 2023

Starch Stärke

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The present study investigates the morphological and cytotoxic properties of starch‐myristic acid complex (SMC) derivatives. We attempted to prepare a SMC by frying. By liquid‐liquid extraction, starch – myristic acid complex nanostructured materials were isolated. X‐ray diffractometers and transmission electron microscopes were used to determine the morphology and crystallization of the extractive. We performed various assays to assess the toxicological profile of starch‐myristic acid complex‐derived nanostructured materials (SMC‐NMs), including cellular viability tests, cellular and nuclear morphological examinations, mitochondrial membrane potential (MMP), and intracellular reactive oxygen species (ROS) measurements. Transmission electron microscopy (TEM) images reveal nanoscale particles between 30 and 90 nm in water fraction‐based SMC‐NMs (WSMC‐NMs) and 160 nm and 250 nm in methanol fraction‐based SMC‐NMs (MSMC‐NMs). The WSMC‐NMs and MSMC‐NMs decreased the cell viability by 77 and 91% at 250 μg/mL, respectively. The SMC‐NMs enhanced necrotic cell death by increasing the level of ROS in human mesenchymal stem cells (hMSCs). The SMC‐NMs altered gene expression within 24 hours. Gene expression of GSTM3 and GSR has explicitly upregulated in a dose‐dependent manner in WSMC‐NMs and MSMC‐NMs exposed cells. Our study found that nanoscale particles may develop during cooking, increasing the risk of diabetes, cardiovascular diseases, and obesity.This article is protected by copyright. All rights reserved

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Preparation strategies, properties highlights, and emerging applications across environmental, biological, and energy industries of silver-loaded graphitic carbon nitride: A critical review

Cong,

Huong,

Dat

et al. 2024

Advances in Colloid and Interface Science

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Synthesis of folic acid loaded g-C3N4/Ag2S nanohybrids for near infrared light mediated photothermal ablation of breast cancer cells

Cited by 6 publications

References 43 publications

Mucilage‐assisted fabrication of molybdenum trioxide nanostructures for photothermal ablation of breast cancer cells

Mucilage‐assisted fabrication of molybdenum trioxide nanostructures for photothermal ablation of breast cancer cells

Morphological, Thermal, and Cytotoxicity Features Assessment of Starch–Myristic Acid Complex‐Derived Nanostructured Materials

Preparation strategies, properties highlights, and emerging applications across environmental, biological, and energy industries of silver-loaded graphitic carbon nitride: A critical review

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