Synthesis of α-Nitro Ketoximes from Styrenes and tert-Butyl Nitrite

Abstract

We have discovered that various α-nitro ketoximes can be synthesized in good yields starting from styrenes and tert-butyl nitrite. It was found that the success of the reaction was critically dependent on the use of a mixture solvent of DMSO and water. The reaction can tolerate a wide variety of substituents including electron-withdrawing and electron-donating groups.

Metal‐Free Regioselective Oxynitration of Acrylamides: Synthesis of 1,2‐Nitro Alcohols

“…Under this trend, tremendous progress in nitration of alkenes using tert ‐butyl nitrite as an eco‐friendly nitrating reagent has been achieved in the past few years ,. In 2015 and 2016, Tan et al . and Kuhakarn et al .…”