2017
DOI: 10.13005/ojc/330238
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Synthesis of Fused-Oxazines from Cyclic Ketoximes Via a-Nitrosoalkenes

Abstract: Cyclic ketoximes having a a-methylene group on reaction with chloramine-T followed by treatment with triethylamine generate a-nitrosoalkenes via a-chloronitroso intermediates, which are further treated with alkenes to give fused-oxazines.

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Cited by 12 publications
(9 citation statements)
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“…Especially, 1,3,4‐oxadiazole is widely studied by the chemists due to its pharmacophore feature for ligand binding . A great number of pharmacological properties have been associated with this small but important core structure such as anti‐inflammatory , antimicrobial , antitubercular , and anticancer . Non‐steroidal anti‐inflammatory drugs (NSAIDs) are good choice to use for the treatment of pain, fever, and inflammation, particularly arthritis .…”
Section: Introductionmentioning
confidence: 99%
“…Especially, 1,3,4‐oxadiazole is widely studied by the chemists due to its pharmacophore feature for ligand binding . A great number of pharmacological properties have been associated with this small but important core structure such as anti‐inflammatory , antimicrobial , antitubercular , and anticancer . Non‐steroidal anti‐inflammatory drugs (NSAIDs) are good choice to use for the treatment of pain, fever, and inflammation, particularly arthritis .…”
Section: Introductionmentioning
confidence: 99%
“…Several biologically active oxadizoles have been reported previously . Biotic capacities of oxadiazoles were also reported in the literature as anticancer , antiproliferative , anti‐HIV , anti‐inflammatory , antitubercular , antimicrobial , anticonvulsant , antimalarial , antihepatitis B viral activities , and many more.…”
Section: Introductionmentioning
confidence: 87%
“…There are several sources of α-nitrosoalkenes as shown in Scheme 1 . Conventional precursors of α-nitrosoalkenes are α-halooximes 1 (or halo-substituted nitroso compounds [ 11 12 ]), which undergo deprotonation/halide elimination upon treatment with a base [ 13 ] ( Scheme 1 , reaction (1)). A disadvantage of this method is that NSA are generated fast and high stationary concentrations are achieved facilitating polymerization.…”
Section: Reviewmentioning
confidence: 99%