Synthesis of Gd doped CdSe nanoparticles for potential optical and MR imaging applications

Li, I-Fang; Yeh, Chen-Sheng

doi:10.1039/b924089f

Cited by 59 publications

(40 citation statements)

References 22 publications

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“…The recently developed Gd 3+ -based NPs such as Gd 2 O 3 -, 43-45,116 NaGdF 4 -, 36,38-41 GdF 3 -, 46,117,118 and Gd 3+ -doped NPs ( e.g ., quantum dots, 119-123 upconversion NPs, 124-126 and carbon dots 127,128 ) have been regarded as promising T 1 CAs because of their controllable size and morphology. By optimizing the reaction parameters during both nucleation and growth, Johnson et al .…”

Section: Factors Influencing Relaxivity Of Mri Contrast Agentsmentioning

confidence: 99%

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

et al. 2017

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Magnetic resonance imaging (MRI) is a highly valuable non-invasive imaging tool owing to its exquisite soft tissue contrast, high spatial resolution, lack of ionizing radiation, and wide clinical applicability. Contrast agents (CAs) can be used to further enhance the sensitivity of MRI to obtain information-rich images. Recently, extensive research efforts have been focused on the design and synthesis of high-performance inorganic nanoparticle-based CAs to improve the quality and specificity of MRI. Herein, the basic rules, including the choice of metal ions, effect of electron motion on water relaxation, and involved mechanisms, of CAs for MRI have been elucidated in detail. In particular, various design principles, including size control, surface modification (e.g. organic ligand, silica shell, and inorganic nanolayers), and shape regulation, to impact relaxation of water molecules have been discussed in detail. Comprehensive understanding of how these factors work can guide the engineering of future inorganic nanoparticles with high relaxivity. Finally, we have summarized the currently available strategies and their mechanism for obtaining high-performance CAs and discussed the challenges and future developments of nanoparticulate CAs for clinical translation in MRI.

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Section: Factors Influencing Relaxivity Of Mri Contrast Agentsmentioning

confidence: 99%

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

et al. 2017

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“…Synthesis of magnetically doped core and core/shell MQDs, emitting in the visible regime and synthesized using non-aqueous solvents have been reported, for e.g. Co and Mn doped CdSe 31 , Cr doped CdSe 32 , Gd doped in CdSe 3 , Mn doped in CdSe 33 , Mn doped in the core of CdS/ZnS 34 and in the shell of core/shell CdSe/Zn 1 - x Mn x S 35 , Mn doped InP 36, 37 , Ni doped CdTeSe/CdS 38 . Many reports on the development of MQDs emitting in the visible regime are available, but very few exist 39 for bi-functional MQDs that emit in the NIR.…”

Section: Introductionmentioning

confidence: 99%

Fe doped CdTeS magnetic quantum dots for bioimaging

et al. 2013

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A facile synthesis of 3-6 nm, water dispersible, near-infrared (NIR) emitting, quantum dots (QDs) magnetically doped with Fe is presented. Doping of alloyed CdTeS nanocrystals with Fe was achieved in situ using a simple hydrothermal method. The magnetic quantum dots (MQDs) were capped with NAcetyl-Cysteine (NAC) ligands, containing thiol and carboxylic acid functional groups to provide stable aqueous dispersion. The optical and magnetic properties of the Fe doped MQDs were characterized using several techniques. The synthesized MQDs are tuned to emit in the Vis-NIR (530-738 nm) wavelength regime and have high quantum yields (67.5-10%). NIR emitting (738 nm) MQDs having 5.6 atomic% Fe content exhibited saturation magnetization of 85 emu/gm[Fe] at room temperature. Proton transverse relaxivity of the Fe doped MQDs (738 nm) at 4.7 T was determined to be 3.6 mM−1s−1. The functional evaluation of NIR MQDs has been demonstrated using phantom and in vitro studies. These water dispersible, NIR emitting and MR contrast producing Fe doped CdTeS MQDs, in unagglomerated form, have the potential to act as multimodal contrast agents for tracking live cells.

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] The studies conducted so far have investigated the relaxometric properties, surface functionalizations, and in vivo MR images of Gd 2 O 3 nanoparticles. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] A particle-size effect on the relaxometric properties of lanthanide oxide nanoparticles has been reported. 1,17,19 However, the effects of ligands on the relaxometric properties of ultrasmall Gd 2 O 3 nanoparticles have rarely been studied.…”

Section: Introductionmentioning

confidence: 99%

Ligand-size and ligand-chain hydrophilicity effects on the relaxometric properties of ultrasmall Gd2O3 nanoparticles

Tegafaw

Lee³

et al. 2016

AIP Advances

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The relaxometric properties of ultrasmall Gd2O3 nanoparticles coated with various ligands were investigated. These ligands include small diacids with hydrophobic chains, namely, succinic acid (Mw = 118.09 amu), glutaric acid (Mw = 132.12 amu), and terephthalic acid (Mw = 166.13 amu), and large polyethylenimines (PEIs) with hydrophilic chains, namely, PEI-1300 (M¯n=1300) and PEI-10000 (M¯n=10000). Ligand-size and ligand-chain hydrophilicity effects were observed. The longitudinal (r1) and transverse (r2) water proton relaxivities generally decreased with increasing ligand-size (the ligand-size effect). The ligand-size effect was weaker for PEI because its hydrophilic chains allow water molecules to access the nanoparticle (the ligand-chain hydrophilicity effect). This result was explained on the basis of the magnetic dipole interaction between the dipoles of the nanoparticle and water proton. In addition, all samples were found to be non-toxic in cellular cytotoxicity tests.

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Synthesis of Gd doped CdSe nanoparticles for potential optical and MR imaging applications

Cited by 59 publications

References 22 publications

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Fe doped CdTeS magnetic quantum dots for bioimaging

Ligand-size and ligand-chain hydrophilicity effects on the relaxometric properties of ultrasmall Gd2O3 nanoparticles

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