Synthesis of glycidoxy spacer on the surface of magnetic nanoparticles and immobilization of albumin

Королев, Д. В.; Гареев, К. Г.; Zorin, V N; Evreinova, N. V.; Postnov, V. N.; Romanova, T. N.

doi:10.1088/1742-6596/1410/1/012069

J. Phys.: Conf. Ser.

2019

DOI: 10.1088/1742-6596/1410/1/012069

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Synthesis of glycidoxy spacer on the surface of magnetic nanoparticles and immobilization of albumin

Д. В. Королев

К. Г. Гареев

V N Zorin

et al.

Abstract: The glycidine spacer was synthesized from three different solvents. It is shown that the samples synthesized from benzene have the highest efficiency. Human albumin was immobilized onto a glycidine spacer. A mechanism for the interaction of albumin with a glycine spacer is proposed. An analysis of the determination of albumin adsorbed by magnetic nanoparticles was performed in this work.

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Cited by 2 publications

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Impact of Metallic, Quantum Dots and Carbon-Based Nanoparticles on Quality and Storage of Albumin Products for Clinical Use

Mehrizi

2021

NANO

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Albumin is the most versatile carrier protein in plasma, possessing multiple functions; a reduced amount of albumin in the body is associated with different kinds of diseases such as hypovolemia and hypoproteinemia. The demand for albumin increased for various indications in shocks, burns, cardiopulmonary bypass, acute liver failure and research applications. Several potential problems associated with the preparation and administration of this substance arise from purity, sterilization process and vascular membrane permeability. The present review discusses the potential of metallic, quantum dots and carbon-based nanocarriers to improve the quality of blood products and the effect of these nanoparticles on albumin products. The effects of these nanoparticles on albumin products with a focus on toxicity aspects, structural alteration, stressing conditions, stabilizing agents and unwanted leakage are highlighted. Our literature review indicated the enhanced efficiency of AuNPs in metallic nanoparticles and better performance of negatively charged QDs on albumin products, which provided important information for possible safe use in medical applications. Moreover, among carbon-based nanoparticles, GO had relatively improved effects on albumin unwanted leakage and fibrillation. This review suggests an agenda for scientists to use and design nanoparticles to improve albumin products for various applications.

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Impact of Metallic, Quantum Dots and Carbon-Based Nanoparticles on Quality and Storage of Albumin Products for Clinical Use

Mehrizi

2021

NANO

View full text Add to dashboard Cite

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Interaction of Nanocomposites Based on the FemOn–SiO2 System with an Electromagnetic Field in an Ultra-Wide Frequency Range

Гареев

2020

Magnetochemistry

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The article describes the interaction of nanocomposites based on the FemOn–SiO2 system with an electromagnetic field (radiation) in an ultra-wide frequency range 0–1021 Hz. The development of the technique based on the sol–gel method for producing nanocomposites is described, which made it possible to achieve superparamagnetic properties in combination with low toxicity when used in vivo and in vitro and a high microwave absorption coefficient, which makes it possible to use the obtained nanocomposites in solving a wide range of practical problems. The most effective methods of exposure and threshold levels of the electromagnetic field, the corresponding modifications of the magnetic structure, crystalline structure and microstructure of nanocomposites are determined.

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Synthesis of glycidoxy spacer on the surface of magnetic nanoparticles and immobilization of albumin

Cited by 2 publications

References 8 publications

Impact of Metallic, Quantum Dots and Carbon-Based Nanoparticles on Quality and Storage of Albumin Products for Clinical Use

Impact of Metallic, Quantum Dots and Carbon-Based Nanoparticles on Quality and Storage of Albumin Products for Clinical Use

Interaction of Nanocomposites Based on the FemOn–SiO2 System with an Electromagnetic Field in an Ultra-Wide Frequency Range

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