Synthesis of graft copolymers of acrylamide for locust bean gum using microwave energy: swelling behavior, flocculation characteristics and acute toxicity study

Giri, Tapan Kumar; Pure, Sanjeet; Tripathi, Dulal Krishna

doi:10.1590/0104-1428.1717

Cited by 39 publications

(35 citation statements)

References 21 publications

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“…The presence of Tween 80 ® at the used concentration was reported not to affect Locust bean gum does not show diffraction peaks, in agreement with its non-crystalline nature. The diffraction patterns obtained after and before spray-drying are similar to each other, and are also similar to those described in the literature [33]. Spray-dried INH retains high crystallinity when compared with RFB, as shown in Figures S1 and S2 (Supplementary Materials).…”

Section: In Vitro Drug Releasesupporting

confidence: 83%

Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles

et al. 2016

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Tuberculosis remains a major global health problem and alternative therapeutic approaches are needed. Considering the high prevalence of lung tuberculosis (80% of cases), the pulmonary delivery of antitubercular drugs in a carrier system capable of reaching the alveoli, being recognised and phagocytosed by alveolar macrophages (mycobacterium hosts), would be a significant improvement to current oral drug regimens. Locust bean gum (LBG) is a polysaccharide composed of galactose and mannose residues, which may favour specific recognition by macrophages and potentiate phagocytosis. LBG microparticles produced by spray-drying are reported herein for the first time, incorporating either isoniazid or rifabutin, first-line antitubercular drugs (association efficiencies >82%). Microparticles have adequate theoretical properties for deep lung delivery (aerodynamic diameters between 1.15 and 1.67 µm). The cytotoxic evaluation in lung epithelial cells (A549 cells) and macrophages (THP-1 cells) revealed a toxic effect from rifabutin-loaded microparticles at the highest concentrations, but we may consider that these were very high comparing with in vivo conditions. LBG microparticles further evidenced strong ability to be captured by macrophages (percentage of phagocytosis >94%). Overall, the obtained data indicated the potential of the proposed system for tuberculosis therapy.

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Section: In Vitro Drug Releasesupporting

confidence: 83%

Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles

et al. 2016

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“…However, when the KPS concentration is raised above 1.30 3 10 23 M, the concentration of radicals increases immensely in the polymerization medium. 33 In the optimization study, the best grafting percent and graft efficiency were found to be 73% and 95%, respectively. 31 Effect of DEAAm Concentration.…”

Section: Optimization Of Graft Copolymerization Conditionsmentioning

confidence: 94%

Thermoresponsive and biocompatible poly(vinyl alcohol)‐graft‐poly(N,N‐diethylacrylamide) copolymer: Microwave‐assisted synthesis, characterization, and swelling behavior

Işıklan

Kazan

2017

J of Applied Polymer Sci

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Novel thermoresponsive poly(vinyl alcohol)-graft-poly(N,N-diethylacrylamide) (PVA-g-PDEAAm) copolymers were prepared by microwave-assisted graft copolymerization using a potassium persulfate/N,N,N 0 ,N 0 -tetramethylethylenediamine (KPS/ TEMED) initiator system. The structures of PVA-g-PDEAAm copolymers were characterized by 1 H-NMR, Fourier transform infrared spectroscopy, differential scanning calorimetry/thermogravimetric analysis, gel permeation chromatography, X-ray diffraction, and scanning electron microscopy. The effects of various process parameters on grafting were systematically studied: microwave power, KPS, monomer and PVA concentrations, and ultraviolet irradiation. Under optimal conditions, the maximum grafting percent and graft efficiency were 101% and 93%, respectively. Furthermore, a lower critical temperature of copolymers was measured in the range 29-31 8C by ultraviolet spectroscopy. The swelling behavior of graft membranes was carried out at various temperatures, and the results showed that the swelling behavior of membranes was dependent on the temperature. In vitro cell culture studies using L929 fibroblast cells confirmed cell compatibility with the PVA-g-PDEAAm copolymer and its membrane, making them an attractive candidate for drug delivery systems.

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“…At excess monomer concentration, the primary radicals attacked the monomer instead of reacting with the CMC backbone. This initiated a homopolymerization reaction to form high ungrafted homopolymer, which led to increase in the viscosity of reaction medium, making it more difficult for the monomer to diffuse and react with the active sites on the CMC backbone, causing lower grafted copolymer hydrogel yield …”

Section: Resultsmentioning

confidence: 99%

“…MH provides a volumetric heating process and improves heating efficiencies compared with conventional techniques . MH has a number of characteristic advantages over conventional thermal processes; MH is simple to use, reduces the required process energy, enhances production yields and reduces the generation of by‐products, and is environmentally friendly . Therefore, MH has become an attractive heating technique.…”

Section: Introductionmentioning

confidence: 99%

Optimization of synthesis condition for carboxymethyl cellulose‐based hydrogel from rice straw by microwave‐assisted method and its application in heavy metal ions removal

Panchan

Niamnuy

Dittanet

et al. 2017

J of Chemical Tech & Biotech

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BACKGROUND An alternative carboxymethyl cellulose‐based biosorbent hydrogel was synthesized by grafting 2‐acrylamido‐2‐methylpropanesulfonic acid (AMPS) onto the prepared carboxymethyl cellulose backbone via microwave heating. Response surface methodology was employed to optimize the hydrogel synthesis condition for maximum gel content with respect to AMPS dose, N,N′‐methylene‐bis‐acrylamide dose, and microwave exposure time. The prepared gels were then characterized and evaluated in terms of their heavy metal ions adsorption performance and reusability. RESULTS The optimum synthesis condition yielded the maximum gel content and maximum equilibrium swelling of 96.33% and 2819 ± 15%, respectively. The Langmuir model fitted the experimental isotherm data well, with maximum adsorption capacity of 86.21, 102.04 and 33.56 mg g‐1 for Cu2+, Pb2+ and Fe3+, respectively. Microwave heating was clearly noted to result in hydrogel of higher porosity and could shorten the synthesis time by 88.33%; the gel content was 7.46% higher compared with that obtained via conventional heating. CONCLUSION Microwave‐assisted heating is a feasible alternative and an efficient technique for CMC‐g‐AMPS hydrogel synthesis. The optimized CMC‐g‐AMPS hydrogel exhibited good performance for Cu2+, Pb2+ and Fe3+ ions removal and was satisfactorily reused, thus contributing to the alleviation of environmental problems caused by discarded rice straw and water contaminated with heavy metal ions. © 2017 Society of Chemical Industry

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Synthesis of graft copolymers of acrylamide for locust bean gum using microwave energy: swelling behavior, flocculation characteristics and acute toxicity study

Cited by 39 publications

References 21 publications

Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles

Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles

Thermoresponsive and biocompatible poly(vinyl alcohol)‐graft‐poly(N,N‐diethylacrylamide) copolymer: Microwave‐assisted synthesis, characterization, and swelling behavior

Optimization of synthesis condition for carboxymethyl cellulose‐based hydrogel from rice straw by microwave‐assisted method and its application in heavy metal ions removal

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