Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Ghosh, Sougata; Bhagwat, Tanay; Kitture, Rohini; Thongmee, Sirikanjana; Webster, Thomas J.

doi:10.3791/63985

Cited by 3 publications

(2 citation statements)

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“…In addition, zeolitic imidazolate framework-8 nanoparticless released by hydrogel can also up-regulate the production and secretion of alkaline phosphatase, collagen 1, and osteocalcin, and promote the osteogenic differentiation of bone marrow mesenchymal stem cells. In addition, Ghosh et al (2022) prepared hybrid nanocomposites by using graphene nanoribbons and nanoparticles of hydroxyapatite, which could potentially improve osteogenesis. A study showed that the silk fibroin/nanohydroxyapatite/hyaluronic acid composite scaffolds had excellent cell proliferation and osteogenic differentiation ability (Wang et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

The application of biomaterials in osteogenesis: A bibliometric and visualized analysis

Wang

Chen

Yang

et al. 2022

Front. Bioeng. Biotechnol.

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Osteogenesis serves an important role in bone tissue repairing. Novel biomaterials are widely prevalent as materials for orthopedic implants due to their biocompatibility and osteogenetic ability. The purpose of this study was to comprehensively analyze hotspots and future trend of biomaterials research in osteogenesis based on bibliometric and visualized analysis. A total of 1,523 papers about biomaterials research in osteogenesis between 2000 and 2021 were included in this study. During the above 20 years, China’s leading position in the global biomaterials research in osteogenesis was obvious, and it was also the country that most frequently participates in international cooperation. Chinese Academy of Sciences was the most productive institution and the leader of research cooperation. Acta Biomaterialia and Biomaterials have published the largest number of articles in the field of biomaterials research in osteogenesis. Meanwhile, Acta Biomaterialia and Biomaterials were also the two journals with the highest total citation frequency. Wu CT, Chang J, Kaplan DL, and Xiao Y all made important contributions in the field of biomaterials research in osteogenesis. At present, there are five research hotspots in the field of biomaterials research in osteogenesis: 1) the immunomodulatory role of biomaterial-related inflammatory; 2) mechanisms of osteogenesis in biomaterials; 3) 3D printing and clinical application of biomaterials; 4) bone tissue engineering for biomaterial osteogenesis; and 5) regenerative medicine for biomaterial osteogenesis. The results of this study showed that mechanisms of osteogenesis in biomaterials, bone tissue engineering for biomaterial osteogenesis, and regenerative medicine for biomaterial osteogenesis will remain research hotspots in the future. International cooperation was also expected to expand and deepen the field of biomaterials research in osteogenesis.

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Section: Discussionmentioning

confidence: 99%

The application of biomaterials in osteogenesis: A bibliometric and visualized analysis

Wang

Chen

Yang

et al. 2022

Front. Bioeng. Biotechnol.

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“…The phytogenic nanoparticles with catalytic activity can be further coupled with solvent impregnated resin (SIR) for their potential application like removal and sensing of refractory pollutants such as dye, metal ions and phenolic compounds from industrial effluents ( Tamang et al, 2022 ). Additionally, these nanoparticles can be functionalized with bioactive principles, drugs, targeting ligands and/or contrast agents for extending their applications as antimicrobial, anticancer, antioxidant, tissue engineering and theranostic agents ( Chandraker et al, 2021b ; Ghosh et al, 2022b ).…”

Section: Resultsmentioning

confidence: 99%

Leucophyllum frutescens mediated synthesis of silver and gold nanoparticles for catalytic dye degradation

et al. 2022

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The application of nanotechnology is gaining worldwide attention due to attractive physico-chemical and opto-electronic properties of nanoparticles that can be also employed for catalytic dye degradation. This study reports a phytogenic approach for fabrication of silver (AgNPs) and gold nanoparticles (AuNPs) using Leucophyllum frutescens (Berl.) I. M. Johnst (Scrophulariaceae) leaf extract (LFLE). Development of intense dark brown and purple color indicated the synthesis of AgNPs and AuNPs, respectively. Further characterization using UV-visible spectroscopy revealed sharp peak at 460 nm and 540 nm for AgNPs and AuNPs, respectively that were associated to their surface plasmon resonance. High resolution transmission electron microscope (HRTEM) revealed the spherical shape of the AgNPs, whereas anisotropic AuNPs were spherical, triangular and blunt ended hexagons. The majority of the spherical AgNPs and AuNPs were ∼50 ± 15 nm and ∼22 ± 20 nm, respectively. Various reaction parameters such as, metal salt concentration, temperature and concentration of the leaf extract were optimized. Maximum synthesis of AgNPs was obtained when 5 mM for AgNO3 reacted with 10% LFLE for 48 h at 50°C. Likewise, AuNPs synthesis was highest when 2 mM HAuCl4 reacted with 10% LFLE for 5 h at 30°C. Energy dispersive spectroscopy (EDS) showed phase purity of both the nanoparticles and confirmed elemental silver and gold in AgNPs and AuNPs, respectively. The average hydrodynamic particles size of AgNPs was 34.8 nm while AuNPs was 140.8 nm as revealed using dynamic light scattering (DLS) that might be due to agglomeration of smaller nanoparticles into larger clusters. ZETA potential of AgNPs and AuNPs were 0.67 mV and 5.70 mV, respectively. X-ray diffraction (XRD) analysis confirmed the crystallinity of the nanoparticles. Fourier transform infrared spectroscopy (FTIR) confirmed that various functional groups from the phytochemicals present in LFLE played a significant role in reduction and stabilization during the biogenic synthesis of the nanoparticles. The bioreduced AgNPs and AuNPs catalytically degraded Rhodamine B dye (RhB) in presence of UV-light with degradation rate constants of 0.0231 s−1 and 0.00831 s−1, respectively. RhB degradation followed a first order rate kinetics with 23.1 % and 31.7% degradation by AgNPs and AuNPs, respectively.

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Microbial Fabrication of Quantum Dots: Mechanism and Applications

Bloch,

Sarkar,

Ghosh

2024

Curr Microbiol

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Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Cited by 3 publications

References 0 publications

The application of biomaterials in osteogenesis: A bibliometric and visualized analysis

The application of biomaterials in osteogenesis: A bibliometric and visualized analysis

Leucophyllum frutescens mediated synthesis of silver and gold nanoparticles for catalytic dye degradation

Microbial Fabrication of Quantum Dots: Mechanism and Applications

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