Synthesis of green solvents from bio-based lactones using heterogeneous copper catalysts

Cavuoto, Denise; Gervasini, Antonella; Zaccheria, Federica; Scotti, Nicola; Marelli, Marcello; Bisio, Chiara; Begni, Federico; Ravasio, Nicoletta

doi:10.1016/j.cattod.2023.114104

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…Among the studied solvents, even the commonly used DMSO can be considered a green solvent [33]. Also, solvents such as 4-formylmorpholine [34], the three studied glymes [35], lactones [36], cyrene [37] and ethyl lactate [38] are commonly considered green. Apart from neat solvents, for the two best-performing systems, binary solvents were also created by mixing these solvents in varying proportions with water.…”

Section: Introductionmentioning

confidence: 99%

ADMET and Solubility Analysis of New 5-Nitroisatine-Based Inhibitors of CDK2 Enzymes

Czeleń,

Jeliński,

Skotnicka

et al. 2023

Biomedicines

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The development of new substances with the ability to interact with a biological target is only the first stage in the process of the creation of new drugs. The 5-nitroisatin derivatives considered in this study are new inhibitors of cyclin-dependent kinase 2 (CDK2) intended for anticancer therapy. The research, carried out based on the ADMET (absorption, distribution, metabolism, excretion, toxicity) methods, allowed a basic assessment of the physicochemical parameters of the tested drugs to be made. The collected data clearly showed the good oral absorption, membrane permeability, and bioavailability of the tested substances. The analysis of the metabolite activity and toxicity of the tested drugs did not show any critical hazards in terms of the toxicity of the tested substances. The substances’ low solubility in water meant that extended studies tested compounds were required, which helped to select solvents with a high dissolving capacity of the examined substances, such as DMSO or NMP. The use of aqueous binary mixtures based on these two solvents allowed a relatively high solubility with significantly reduced toxicity and environmental index compared to pure solvents to be maintained, which is important in the context of the search for green solvents for pharmaceutical use.

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