Synthesis of Half‐Channels by the Anionic Polymerization of Ethylene Oxide Initiated by Modified Cyclodextrin

Abstract

Amphiphilic star‐shaped oligomers are produced by anionic polymerization of ethylene oxide (EO) using per‐2,3‐di‐O‐heptyl‐β‐(or γ)cyclodextrins as initiators — a versatile way of synthesizing artificial channels bearing one polyEO branch per glucose unit. The behavior of the amphiphilic molecules in lipid membranes is studied by electrical measurements, which confirms the formation of transient, well‐defined dimeric ionic channels (see figure).

β‐Cyclodextrin‐Based Star Amphiphilic Copolymers: Synthesis, Characterization, and Evaluation as Artificial Channels

“…Discrete 1 pA current jumps were observed after 700 s for an applied voltage of 100 mV. This intensity value is comparable with the one previously reported for monomolecular star polymer CD‐based artificial channels . The analysis of the current distribution (Figure S19D, Supporting Information) shows a well‐defined distribution of three main current peaks (0 pA for the membrane, −1 pA for a current jump, and −5 pA).…”

“…Low X n were targeted for analysis purpose and for the studies of lipid bilayer–polymer interactions later on . The conversion of the monomer was determined by 1 H NMR.…”

“…[21] Some articles describe the use of cyclodextrins as a core of star macromolecular architectures for different applications such as drug and gene delivery, [22,23] nanocrystal clusters, [24] compatibilization, [25] thermoresponsive self-assemblies, [26] and artificial channels. [27][28][29] Artificial channels are used in filtration processes [30] or as antibiotics. [31] In this study, we report the synthesis of regular 14-branched star homopolymers and copolymers with a β-cyclodextrin core by anionic ring-opening polymerization of epoxides.…”

Chemical Sensors Based on New Polyamides Biobased on (Z) Octadec‐9‐Enedioic Acid and β‐Cyclodextrin

“…During the past decades, CDs have successfully been used as drug carriers to improve solubility, chemical stability, dissolution, and bioavailability or decrease unfavorable side‐effects of drugs. Thus, these host molecules found vast applications as artificial enzymes, drug carriers, nanopores, catalyst, and chemosensors, to name but a few . Most of CD‐based polymers are star polymers with a CD core or linear polymer with dangling CD grafted on a macromolecular backbone .…”

“…Thus, these host molecules found vast applications as artifi cial enzymes, drug carriers, nanopores, catalyst, and chemosensors, to name but a few. [ 29,[42][43][44][45][46] Most of CD-based polymers are star polymers with a CD core [47][48][49][50] or linear polymer with dangling CD grafted on a macromolecular backbone. [51][52][53] However, these strategies involved monomers from fossil resources.…”