Synthesis of hydroxyapatite fibers using electrospinning: A study of phase evolution based on polymer matrix

Sebastian, Tutu; Preisker, Theresia; Gorjan, Lovro; Graule, Thomas; Aneziris, Christos G.; Clemens, Frank

doi:10.1016/j.jeurceramsoc.2020.01.070

Cited by 20 publications

(7 citation statements)

References 23 publications

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“…Generally, a high-voltage electric field is used to pull the electrospinning colloidal solution containing organic solutes, vaporized solvents and HANPs additives in the syringe into fibers, so that the solvent is completely volatilized between the needle and the collector to obtain a HANPs composite fibrous membrane [65][66][67][68]. To achieve the desired viscosity for electrospinning, and to adjust the voltage, flow rate, and spinning distance to prepare HANPs composite fiber membranes, it is necessary to carefully tune the dispersed HANPs in the polymer matrix [69]. HANPs into CS/gelatin to form reinforced-polyelectrolyte complex nanofibers as encapsulation for controlled release of tetracycline hydrochloride (TCH) [72].…”

Section: Electrospun Composites Of Hanps/organicsmentioning

confidence: 99%

“…Electrospinning is a direct, inexpensive, and unique method for producing novel fibers with diameters of 100 nm and even smaller [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ]. In fibrous membranes, polymer solutions, suspensions of HANPs containing drug and protein additives are electrospun in an electric field ( Figure 3 ), since electrospinning is a simple, convenient, and low-cost nanofiber fabrication technique.…”

Section: Recent Strategies For Compounding Natural and Synthetic Poly...mentioning

confidence: 99%

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Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

et al. 2022

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Hydroxyapatite (HA), especially in the form of HA nanoparticles (HANPs), has excellent bioactivity, biodegradability, and osteoconductivity and therefore has been widely used as a template or additives for drug delivery in clinical applications, such as dentistry and orthopedic repair. Due to the atomically anisotropic distribution on the preferred growth of HA crystals, especially the nanoscale rod-/whisker-like morphology, HA can generally be a good candidate for carrying a variety of substances. HA is biocompatible and suitable for medical applications, but most drugs carried by HANPs have an initial burst release. In the adsorption mechanism of HA as a carrier, specific surface area, pore size, and porosity are important factors that mainly affect the adsorption and release amounts. At present, many studies have developed HA as a drug carrier with targeted effect, porous structure, and high porosity. This review mainly discusses the influence of HA structures as a carrier on the adsorption and release of active molecules. It then focuses on the benefits and effects of different types of polymer-HA composites to re-examine the proteins/drugs carry and release behavior and related potential clinical applications. This literature survey can be divided into three main parts: 1. interaction and adsorption mechanism of HA and drugs; 2. advantages and application fields of HA/organic composites; 3. loading and drug release behavior of multifunctional HA composites in different environments. This work also presents the latest development and future prospects of HA as a drug carrier.

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Section: Electrospun Composites Of Hanps/organicsmentioning

confidence: 99%

Section: Recent Strategies For Compounding Natural and Synthetic Poly...mentioning

confidence: 99%

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

et al. 2022

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“…The size of the cHAp clusters varies over a wide range (1-15 µm). There are many attempts to prepare hydroxyapatite-biopolymer composites with appropriate bioactive properties for biomedical use or for bone tissue engineering; however, the majority of them use poly(l-lactic acid) (PLLA), poly(e-caprolactone), chitosan, and gelatines matrices [60][61][62][63][64][65][66][67], and only a few of them apply PVP or CA [68][69][70]. There are many attempts to prepare hydroxyapatite-biopolymer composites with appropriate bioactive properties for biomedical use or for bone tissue engineering; however, the majority of them use poly(l-lactic acid) (PLLA), poly(e-caprolactone), chitosan, and gelatines matrices [60][61][62][63][64][65][66][67], and only a few of them apply PVP or CA [68][69][70].…”

Section: Morphological Characterisation Of Pure and Chap-loaded Pvp And Camentioning

confidence: 99%

Comparison of the Morphological and Structural Characteristic of Bioresorbable and Biocompatible Hydroxyapatite-Loaded Biopolymer Composites

et al. 2021

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Calcium phosphate (CaP)-based ceramic–biopolymer composites can be regarded as innovative bioresorbable coatings for load-bearing implants that can promote the osseointegration process. The carbonated hydroxyapatite (cHAp) phase is the most suitable CaP form, since it has the highest similarity to the mineral phase in human bones. In this paper, we investigated the effect of wet chemical preparation parameters on the formation of different CaP phases and compared their morphological and structural characteristics. The results revealed that the shape and crystallinity of CaP particles were strongly dependent on the post-treatment methods, such as heat or alkaline treatment of as-precipitated powders. In the next step, the optimised cHAp particles have been embedded into two types of biopolymers, such as polyvinyl pyrrolidone (PVP) and cellulose acetate (CA). The pure polymer fibres and the cHAp–biopolymer composites were produced using a novel electrospinning technique. The SEM images showed the differences between the morphology and network of CA and PVP fibres as well as proved the successful attachment of cHAp particles. In both cases, the fibres were partially covered with cHAp clusters. The SEM measurements on samples after one week of immersion in PBS solution evidenced the biodegradability of the cHAp–biopolymer composites.

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“…Microwave sintering and microwave heating can be used to process bioceramic powders. Microwave radiation saves time, energy, and associated processing costs [6,18].…”

Section: Literature Reviewmentioning

confidence: 99%

Influence of Technological Manufacturing Conditions on the Porosity of Calcium-Phosphate Scaffolds

Chernobrovchenko¹,

Dyadyura²,

Balynskyi³

et al. 2021

JES

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The implantation of bone substitutes depends on the material’s osteoconductive potential and the structure’s porosity Porosity is a characteristic feature of most materials. The porosity of materials has a strong influence on some of their properties, both structural and functional. An essential requirement for bone scaffolds is porosity, which guides cells into their physical structure and supports vascularization. The macroporosity should be large enough and interdependent for bone ingrowth to occur throughout the entire volume of the implant. The pore size for cell colonization in bioceramics is approximately 100 μm. Pores larger than this value promote bone growth through the material. This pore size allows the flow of growth factors and cell adhesion and proliferation, allowing the formation of new bone and developing the capillary system associated with the ceramic implant. Porosity also affects the rate of resorption of ceramics: the larger the number of micropores, the higher the dissolution rate. The investigated properties were elastic moduli, ultimate strength, compressive strength, and average apparent density. The results obtained in this work are consistent with previous studies, proving the positive role of microporosity in osseointegration and bone formation.

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Synthesis of hydroxyapatite fibers using electrospinning: A study of phase evolution based on polymer matrix

Cited by 20 publications

References 23 publications

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

Comparison of the Morphological and Structural Characteristic of Bioresorbable and Biocompatible Hydroxyapatite-Loaded Biopolymer Composites

Influence of Technological Manufacturing Conditions on the Porosity of Calcium-Phosphate Scaffolds

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