Synthesis of hydroxyapatite for biomedical applications

Szcześ, Aleksandra; Hołysz, Lucyna; Chibowski, Emil

doi:10.1016/j.cis.2017.04.007

Cited by 586 publications

(305 citation statements)

References 179 publications

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“…However, their poor biological activity limits their extensive use in medical applications and therefore needs to be enhanced [1][2][3]. Conversely, owing to high biocompatibility, bioactivity, and osteoconductivity, calcium orthophosphate (CaP) ceramics, such as hydroxyapatite (HAP), have received much attention in the field of tissue engineering and have been clinically employed either as coating or as scaffold in orthopaedics and dentistry [3][4][5]. In this context, CaP-coated carbon fibers or cloth, combining the high biocompatibility of CaP with the properties of carbon fiber, appear as promising biomaterials for bone repair and regeneration [2,3,6].…”

Section: Introductionmentioning

confidence: 99%

“…In the past decades, several methods including plasma spray, radio-frequency sputtering, pulsed laser-deposition, sol-gel routes, electrophoretic methods, and electrochemical deposition have been reported for CaP deposition onto implant surfaces [5,[7][8][9]. Among these, the electrochemical technique is particularly attractive for efficiently coating highly irregular materials at ambient temperatures and has been already applied for metal substrates or porous carbon composites [1][2][3][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development and Characterization of Biomimetic Carbonated Calcium-Deficient Hydroxyapatite Deposited on Carbon Fiber Scaffold

Picard

Olivier

Delpeux

et al. 2018

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Calcium phosphate and derivatives have been known for decades as bone compatible biomaterials. In this work, the chemical composition, microtexture, and structure of calcium phosphate deposits on carbon cloths were investigated. Three main types of deposits, obtained through variation of current density in using the sono-electrodeposition technique, were elaborated. At low current densities, the deposit consists in a biomimetic, plate-like, carbonated calcium-deficient hydroxyapatite (CDA), likely resulting from the in situ hydrolysis of plate-like octacalcium phosphate (OCP), while at higher current densities the synthesis leads to a needle-like carbonated CDA. At intermediate current densities, a mixture of plate-like and needle-like carbonated CDA is deposited. This established that sono-electrodeposition is a versatile process that allows the coating of the carbon scaffold with biomimetic calcium phosphate while tuning the morphology and chemical composition of the deposited particles, thereby bringing new insights in the development of new biomaterials for bone repair.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Biomimetic Carbonated Calcium-Deficient Hydroxyapatite Deposited on Carbon Fiber Scaffold

Picard

Olivier

Delpeux

et al. 2018

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“…HA structure is based on calcium phosphate having good biocompatibility, osteoconductivity, and bioactivity, high rigidity, and low elasticity. In order to improve their mechanical properties, some HA mediated PHB composites had been prepared for dental and orthopedic implants . Shishatskaya et al developed a hybrid composite based on PHB and HA using the compression molding.…”

Section: Phb Based Biocompositesmentioning

confidence: 99%

“…In order to improve their mechanical properties, some HA mediated PHB composites had been prepared for dental and orthopedic implants. 88 Shishatskaya et al 89…”

Section: Phb/hydroxyapatite Compositementioning

confidence: 99%

Recent developments in the synthesis of poly(hydroxybutyrate) based biocomposites

Raza

Noor

Khalil

2019

Biotechnology Progress

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Poly(hydroxybutyrate) (PHB) has become an attractive biomaterial in research and development for past few years. It is natural bio‐based aliphatic polyester produced by many types of bacteria. Due to its biodegradable, biocompatible, and eco‐friendly nature, PHB can be used in line with bioactive species. However, high production cost, thermal instability, and poor mechanical properties limit its desirable applications. So there is need to incorporate PHB with other materials or biopolymers for the development of some novel PHB based biocomposites for value addition. Many attempts have been employed to incorporate PHB with other biomaterials (or biopolymers) to develop sustainable biocomposites. In this review, some recent developments in the synthesis of PHB based biocomposites and their biomedical, packaging and tissue engineering applications have been focused. The development of biodegradable PHB based biocomposites with improved mechanical properties could be used to overcome its native limitations hence to open new possibilities for industrial applications.

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“…HAp can be artificially synthesized using various processes (Komuro, Sasano, Horiuchi, Yamashita, & Nagai, 2019;Szczes, Holysz, & Chibowski, 2017). When synthetic HAp is used with cells in the clinical setting, the biomimetic mineralization process should be considered.…”

Section: Introductionmentioning

confidence: 99%

An oriented hydroxyapatite film with arrayed plate‐like particles enhance chondrogenic differentiation of ATDC5 cells

Komuro

Wint

Horiuchi

et al. 2019

J Biomedical Materials Res

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Osteochondral defects of articular cartilage cannot regenerate spontaneously. For its surgical treatment, advancements in cartilage tissue engineering have particularly focused on subchondral bone lesions that tend to delay healing. Therefore, it is important to understand interactions between subchondral bone and chondrocytes.This study aimed to investigate the behavior of chondrogenic ATDC5 cells on oriented hydroxyapatite (HAp) films that mimic bone surfaces. HAp nanoparticles prepared herein were needle like and plate like. HAp films were formed through selforganization of the nanoparticles and had 2D structures regularly arrayed with the particles. Both films prominently comprised a-plane orientation surfaces but differed in the degree of hydrophilicity because of the patterns of particle self-assembly.ATDC5 cells cultured on the HAp film with plate-like particles could adhered in a shorter period but could not spread. The adhesive force of cells was weaker with the hydrophilic surface than with other surfaces, as determined using a trypsin-based cell detachment assay. In addition, ATDC5 cells displayed enhanced proliferation and chondrogenic differentiation. Our results suggest that the oriented HAp film formed using plate-like particles provided chondrogenic cells with a desired scaffold as that of subchondral bone to increase cell proliferation and differentiation. K E Y W O R D S cell spreading, chondrogenic differentiation, hydroxyapatite film, orientation, osteochondral defect

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Synthesis of hydroxyapatite for biomedical applications

Cited by 586 publications

References 179 publications

Development and Characterization of Biomimetic Carbonated Calcium-Deficient Hydroxyapatite Deposited on Carbon Fiber Scaffold

Development and Characterization of Biomimetic Carbonated Calcium-Deficient Hydroxyapatite Deposited on Carbon Fiber Scaffold

Recent developments in the synthesis of poly(hydroxybutyrate) based biocomposites

An oriented hydroxyapatite film with arrayed plate‐like particles enhance chondrogenic differentiation of ATDC5 cells

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