Synthesis of Hydroxyapatite with Antibacterial Properties Using a Microwave-Assisted Combustion Method

Abstract

The prevention of implant-associated infections has been increasing clinically in orthopedic surgery. Hydroxyapatite with antibacterial properties was synthesized using a microwave-assisted combustion method. High crystallinity at low temperature can be achieved using this method. The synthesized hydroxyapatite exhibited a superior clear zone for both Gram-positive and Gram-negative bacteria. Electron spin resonance (ESR) and X-ray photoelectron spectroscopy (XPS) were used for the radical investigation. The application of intelligent ink testing and an antioxidant assay using DPPH reduction were also used to confirm the existence of radicals. These techniques provided data confirming that radicals are responsible for the antibacterial properties. The synthesized antibacterial hydroxyapatite would be a good candidate for the prevention any infection with medical implants and injection materials causing failure in bone repair.

Comparative analysis and antibacterial properties of thermally sintered apatites with varied processing conditions

“…Currently there have been several studies to synthesize HA with antibacterial properties. These studies are mainly focusing on modifying HA by incorporating 59 or doping 60 different amounts of metal ions using different methods 61,62 such as Fe 2+ , Cu 2+ , Zn 2+ , Ag + , Ti + , Co 3+ , and Ni 3+ ions which are known to have antibacterial properties 63,64 . For example one study reveals that leaching of Cu 2+ ion lead lysis of bacterial cells 64 .…”

Effectiveness of Antibacterial Surfaces in Osseointegration of Titanium Dental Implants: A Systematic Review

“…In our review, the study by Ding and colleagues [ 21 ] evaluated in mice, the formation of new bone on HA (cathodic sputtering) coated implant surfaces treated with DC in an oral environment, concluding that this coating would promote bone apposition around the implant. However, HA has been used as a vehicle for antibiotic delivery because commercial HA itself shows no activity against Gram-positive and Gram-negative bacteria [ 56 , 57 ]. Nevertheless, some studies have pointed out the need to evaluate the biocompatibility and tissue integration capacity of PEO-coated surfaces, as well as their corrosion resistance and antibacterial capacity in vivo [ 58 , 59 , 60 , 61 , 62 ].…”

Multifunctional Hydroxyapatite/Silver Nanoparticles/Cotton Gauze for Antimicrobial and Biomedical Applications

“…The Ag:HAp NPs concentration had little influence on the bacterial growth (P. stuartii). Lamkhao et al [54] synthesized HAp powder with antibacterial properties using a microwave-assisted combustion method. The result of this study confirms that radicals were responsible for the antibacterial properties.…”