Synthesis of cis-9-Cyano-l,10-dimethyl-6-ethylenedioxy-1-octalin and its Conversion into an Intermediate for a Synthesis of Thelepogine

Abstract

The synthesis of cis-9-cyano-1,10-dimethyl-6-ethylenedioxy-1-octalin, the structure of which has been determined by X-ray crystallography, is described. Also described is the conversion of this compound into an octalone having the functionality and stereochemistry appropriate to its use as an intermediate in a total synthesis of thelepogine.