Synthesis ofcis-Fused Bicyclic Systems by Radical Cyclization Approach: Formal Synthesis of Ethisolide andiso-Avenaciolide

Sequential Vinyl Radical Cyclization/Fixation of Carbon Dioxide through Electrochemical Reduction of Vinyl Bromide in the Presence of an Electron‐Transfer Mediator

“…Reaction with Bu 3 SnH/AIBN generates av inyl radicala tt he carbon with the bromine or iodine atom, which can also undergo efficient radicalc yclization to afford unsaturated carbo-and heterocycles. [3][4][5][6][7][18][19][20] As organotin reagents such as Bu 3 SnH are known to be hazardous,a ne nvironmentally benign alternative method for generating vinyl radicals without the use of hazardous reagentsi sd esirable. Samarium diiodide is au seful reducinga gent for generation of av inyl radical by one-electronr eduction of vinyl bromide.…”