Synthesis of N‐acetyl‐N‐(3‐amino‐2,4,6‐triiodophenyl)‐ β‐aminoalkanoic acids suited for use as oral cholecystographic agents

Abstract

The reaction of m‐nitroaniline with α,β unsaturated acids like acrylic acid, methacrylic acid and crotonic acid gives N‐(m‐nitrophenyl)‐β‐aminoalkanoic acids which are converted to N‐acetyl‐N‐(3‐amino‐2,4,6‐triiodophenyl)‐β‐aminoalkanoic acids by successive acetylation, reduction and iodination. N‐Acetyl‐N‐(3‐amino‐2,4,6‐triiodophenyl)‐β‐aminoisobutyric acid* was found to be an excellent oral cholecystographic agent of low toxicity.