Synthesis of N-Lauroyl Sarcosine by Amidocarbonylation: Comparing Homogeneous and Heterogeneous Palladium Catalysts

Abstract

An improved system for the synthesis of N-acyl amino acids via Pd-catalyzed amidocarbonylation is reported. Utilizing inexpensive Pd black gives the industrially important surfactant N-lauroyl sarcosine in excellent yields (95%) on a multi-gram scale. Advantages of the new system include reusability, decreased process temperature, and, importantly, drastically decreased co-catalyst loading.

Stable and Surface‐active Co Nanoparticles Formed from Cation (x) Promoted Au/x‐Co3O4 (x=Cs) as Selective Catalyst for [2+2+1] Cyclization Reactions

“…The products of these reactions have found usage in several biologically active pharmaceuticals and vital natural products [1,2] . Dicobalt octacarbonyl has been broadly used in amidocarbonylation, [3] carbonylation, [4] Pauson‐Khand, [5] and hydroformylation [6] reactions. These cobalt carbonyl compounds are versatile reagents among metal carbonyls for organic and inorganic syntheses.…”

“…The cation-promoted catalysts were synthesized via the deposition-precipitation method with urea and employed as an active catalyst for inter-and intramolecular PK reactions. The reactions were carried out with excellent selectivity and yield to the desired cyclopentenone products under CO atmosphere; though more favorable for the intra PKR, with catalytic activity in order of (5 wt.%) Au/Co 3…”