Synthesis of <i>N</i>-substituted dibenzoazepine–pyridazine derivatives as potential neurologically active drugs

Erdoğan, Musa; Daştan, Arif

doi:10.1080/00397911.2020.1828925

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…The tricyclic framework of octahydropyrrolo [1,2-a]pyrazine A has the ability to interact with IAPs via van der Waal forces, which promote cell death. However, octahydropyrrolo[1,2-a]pyrazine A 288 was found to be metabolically less stable [133]. The interesting biomimetic behavior of this heterocyclic scaffold prompted synthetic efforts toward the synthesis of its derivatives with improved metabolic stability.…”

Section: Synthesis Of Drugsmentioning

confidence: 99%

Simmons–Smith Cyclopropanation: A Multifaceted Synthetic Protocol toward the Synthesis of Natural Products and Drugs: A Review

Munir,

Zahoor,

Javed

et al. 2023

Molecules

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Simmons–Smith cyclopropanation is a widely used reaction in organic synthesis for stereospecific conversion of alkenes into cyclopropane. The utility of this reaction can be realized by the fact that the cyclopropane motif is a privileged synthetic intermediate and a core structural unit of many biologically active natural compounds such as terpenoids, alkaloids, nucleosides, amino acids, fatty acids, polyketides and drugs. The modified form of Simmons–Smith cyclopropanation involves the employment of Et2Zn and CH2I2 (Furukawa reagent) toward the total synthesis of a variety of structurally complex natural products that possess broad range of biological activities including anticancer, antimicrobial and antiviral activities. This review aims to provide an intriguing glimpse of the Furukawa-modified Simmons–Smith cyclopropanation, within the year range of 2005 to 2022.

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Section: Synthesis Of Drugsmentioning

confidence: 99%

Simmons–Smith Cyclopropanation: A Multifaceted Synthetic Protocol toward the Synthesis of Natural Products and Drugs: A Review

Munir,

Zahoor,

Javed

et al. 2023

Molecules

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show abstract

“…1,2 The development of tiny molecular drugs is a crucial driver of sales growth for large pharmacies and denes new research and development patterns for pharmaceutical rms. [3][4][5][6][7][8][9][10][11] Pharmaceutical industries strive to produce safe and inexpensive drugs while keeping pace with the pharmaceutical market. In this regard, investigating new synthetic approaches like "transition metal catalyzed reactions" for rapid access to massive hybrid libraries with facile and cost-effective operating methods is valuable.…”

Section: Introductionmentioning

confidence: 99%

Applications of palladium-catalyzed C–N cross-coupling reactions in pharmaceutical compounds

et al. 2023

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“…The dibenzo[ b , f ]azepine ( 1a ) scaffold ( Figure 1 ) is featured in commercial pharmaceuticals [ 1 ] and other lead compounds [ 2 – 4 ], ligands [ 5 – 6 ] and in materials science with possible applications in organic light emitting diodes (OLEDs) [ 7 ] and dye-sensitized solar cells (DSSCs) [ 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Strategies in the synthesis of dibenzo[b,f]heteropines

Maier¹,

Bezuidenhoudt²,

Marais³

2023

Beilstein J. Org. Chem.

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The dibenzo[b,f]azepine skeleton is important in the pharmaceutical industry, not only in terms of existing commercial antidepressants, anxiolytics and anticonvulsants, but also in reengineering for other applications. More recently, the potential of the dibenzo[b,f]azepine moiety in organic light emitting diodes and dye-sensitized solar cell dyes has been recognised, while catalysts and molecular organic frameworks with dibenzo[b,f]azepine derived ligands have also been reported. This review provides a brief overview of the different synthetic strategies to dibenzo[b,f]azepines and other dibenzo[b,f]heteropines.

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Synthesis of N-substituted dibenzoazepine–pyridazine derivatives as potential neurologically active drugs

Cited by 6 publications

References 27 publications

Simmons–Smith Cyclopropanation: A Multifaceted Synthetic Protocol toward the Synthesis of Natural Products and Drugs: A Review

Simmons–Smith Cyclopropanation: A Multifaceted Synthetic Protocol toward the Synthesis of Natural Products and Drugs: A Review

Applications of palladium-catalyzed C–N cross-coupling reactions in pharmaceutical compounds

Strategies in the synthesis of dibenzo[b,f]heteropines

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