Synthesis of N¹‐tritylethane‐1,1,2,2‐d₄‐1,2‐diamine: a novel mono‐protected C‐deuterated ethylenediamine synthon

Abstract

A convenient and high‐yield synthesis for N1‐tritylethane‐1,1,2,2‐d4‐1,2‐diamine, a novel mono‐protected ethylenediamine‐C‐d4, is reported. N1‐tritylethane‐1,1,2,2‐d4‐1,2‐diamine was prepared in three steps from ethylene oxide‐d4 in a combined yield in the range 68–76%. Also reported is a synthesis of ethylenediamine‐C‐d4 in two steps from 1,2‐dibromoethane‐d4 in a combined yield in the range 61–65%.