Synthesis of N-vinylpyrrolidone/Acrylic acid nanoparticles for drug delivery: Method optimization

Abstract

There are various approaches to deliver therapeutic agents to the preferred target. Polymeric nanoparticles were found to have pleasing suitability as a drug carrier. The goal of this research was to optimize the synthesis method to obtain the desirable %yield and particle properties of the new biocompatible polymer-based nanoparticles. The non-toxic polymer, N-vinyl pyrrolidone (NVP) and a widely used hydrophilic biocompatible acrylic acid (AA) monomer were used to form the drug nanocarriers. The synthesis method was optimized by changing the types of initiator (KPS or V50) and the monomers molar ratio (NVP:AA). It was found that by varying both the monomer molar ratio and the type of reaction initiator, did not have significant effect on the physicochemical characteristics of the nanocarriers. The FTIR spectra of all products exhibited the peaks of carboxylic acid, carbonyl, and tertiary amine functional group vibration. The particle size of the nanocarriers was in the range of 173.6 ± 18.4 to 201.4 ± 17.1 nm with negative surface charge. However, the yield obtained increased as the initiator was altered from KPS to V50, and when the acrylic acid molar ratio was increased from 1:1 to 1:3. In conclusion, changing the initiator and monomer molar ratio may affect the physicochemical properties of the nanocarriers and the %yield of the nanocarrier product. Further investigations are essential to obtain the favorable drug nanocarriers for drug delivery.

Development and Evaluation of Novel Water-Based Drug-in-Adhesive Patches for the Transdermal Delivery of Ketoprofen

“…PVPAA copolymer was synthesized by a polymerization reaction between NVP and AA at a monomer molar ratio of 1:3. A previous study found that the % yield of this ratio was almost twice as great as that obtained at a monomer ratio of 1:1 [12]. The synthesis scheme is presented in Figure 1.…”

“…PVPAA was synthesized using a surfactant-free emulsion polymerization reaction between NVP and AA. The synthesis was modified from a previously reported procedure [12]. Briefly, 0.05-0.2%wt V50 (the initiator) was dissolved in 50 mL of deionized water heated at around 70 • C. The mixture was purged with nitrogen gas to create an inert environment.…”

“…N-vinylpyrrolidone (NVP) and acrylic acid (AA) are water-soluble monomers, which are commonly used to produce a polymer with a high biocompatibility and low toxicity [12]. Chain polymerization techniques are used to synthesize poly (N-vinylpyrrolidoneco-acrylic acid) (PVPAA) polymeric nanoparticles (NPs) from NVP and AA to deliver cisplatin for the treatment of oral cancer [12]. Poly(methyl vinyl ether-alt-maleic anhydride) (PMVEMA) is a water-soluble, biocompatible, and nontoxic polymer.…”

Preactivated-thiolated polyacrylic acid/1-vinyl pyrrolidone nanoparticles as nicotine carriers for smoking cessation

“…The PNPs were synthesized in accordance with our previous study using acrylic acid (AA) and 1-vinyl-2-pyrrolidone (VP) as monomers for the synthesis reaction. 24 Then, the PNPs were conjugated with thiol groups and preactivated with 2MNA. VP is a hydrophilic monomer and commonly acquired as a PNP stabilizer.…”

Review of Possible Applications of Nanofibrous Mats for Wound Dressings

“…Th eir high surface-to-volume ratio enables improved interactions with the environment, making them promising for wound care, drug delivery and biotechnology applications. Nanofi bres can thus be used for biomedical applications such as tissue engineering, wound healing processes and targeted drug delivery systems [3][4][5][6][7][8][9]. According to the results of several research groups, nanofi brous mats have the ability to absorb large concentrations of wound exudates without causing infections, and release anti-microbial and anti-infl ammatory agents.…”