Synthesis of <i>β</i>‐Ketoamide Curcumin Analogs for Anti‐Diabetic and <scp>AGE</scp>s Inhibitory Activities

Banuppriya, Govindharasu; Sribalan, Rajendran; Fathima, Sulthan Alavudeen Rizwan; Padmini, Vediappen

doi:10.1002/cbdv.201800105

Cited by 16 publications

(1 citation statement)

References 25 publications

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“…The chemoselective olefination at the C4 position was achieved under modified borate conditions. For example, acetoacetanilides 475 condensed with vanillin 476 to form the γ , δ ‐unsaturated acetoacetanilides 477 (Scheme 98c) [214] …”

Section: Reactivities Of β‐Keto Amidesmentioning

confidence: 99%

β‐Keto Amides: A Jack‐of‐All‐Trades Building Block in Organic Chemistry

Zheng

et al. 2021

Eur J Org Chem

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β‐Keto amides are a versatile class of compounds that find wide applications in organic chemistry owing to the juxtaposition of multiple reaction sites within their molecular structures. Due to the importance of β‐keto amides in modern organic chemistry, numerous novel preparation methods, synthetic applications and unprecedented reactivities have been recorded over the past decade. Taking advantage of transition‐metal‐catalysis and organocatalysis, β‐keto amides have emerged into a jack‐of‐all‐trades building block for many stereoselective or tandemized multicomponent reactions. But so far, no reviews have been documented on these recent achievements with β‐keto amides. Our Review aims to provide a thorough summary regarding: (a) the synthesis of β‐keto amides, (b) the reactivities of β‐keto amides, (c) the synthetic applications of β‐keto amides in various important heterocyclic compounds, and (d) the coordination of β‐keto amides with main group elements and transition metals and the relevant applications.

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Section: Reactivities Of β‐Keto Amidesmentioning

confidence: 99%