Synthesis of imidazole derivatives: Ester and hydrazide compounds with antioxidant activity using ionic liquid as an efficient catalyst

Abstract

The pyrrolidinium hydrogen sulfate (PHS) was used as an excellent ionic liquid catalyst for the preparation of many imidazoles moiety, which have biologically application via one-pot multicomponent reaction. Imidazoles were afforded through the reaction of equimolar from 1,2-diphenylethane-1,2-dione, ammonium acetate, different aromatic aldehydes, and ethyl glycinate hydrochloride.This method has the advantages of giving excellent yield, shortened reaction times, and ease of establishment. Moreover, the yielded of imidazoles components can be purified and crystallized by a nonchromatographic technique, and the catalyst can be reused. These entire novel synthesized components have been identified by spectral data: IR, NMR and mass spectra. These compounds have an in vivo antioxidant activity on experimental animals (rats).

Design, Synthesis, and Antibacterial Screening of Some Novel Heteroaryl-Based Ciprofloxacin Derivatives as DNA Gyrase and Topoisomerase IV Inhibitors

“…Continuing our quest to find a compound with improved antimicrobial properties [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ], the current study describes the synthesis and structure elucidation of Fluoroquinolone(ciprofloxacin)-based hybrids containing various heterocycle derivatives, as well as antimicrobial activity evaluation using various strains of Gram-positive ( S. aureus and B. subtilis ), Gram-negative ( E. coli and P. aeruginosa ), and fungi ( A. flavus and C. albicans ). In addition, the inhibitory activity of the most active compounds against E. coli DNA gyrase and topoisomerase IV has been identified as a potential molecular target.…”

The Practical Utility of Imidazolium Hydrogen Sulfate Ionic Liquid in Fabrication of Lignin-Based Spheres: Structure Characteristic and Antibacterial Activity

“…In the ATR spectrum of 1-(propoxymethyl)-1H-imidazolium hydrogen sulfate the functional groups of the used ionic liquid are visible. There are the characteristic bands, which are related to cation including the peak occurring at wavenumber 3300 cm −1 corresponds to the stretching vibrations of the -NH group ( Abdelhamid et al, 2020 ). Moreover, there is a wide band that is responsible for stretching vibrations of -CH from 2,970 cm −1 to 2,900 cm −1 and of N-CH 3 at the maximum of wavenumber at 2800 cm −1 .…”

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“…Imidazole derivatives are important and famous heterocyclic compound which shows the general and key structure of features of a variety of medicinal Pharmaceutical and natural products. Essential and synthetic imidazole derivatives occupy the main place among pharmaceutically and medicinally important compounds due to their different interesting and widespread medicinal Pharmaceutical and biological activity such as anti-oxidant [1][2] , antiviral [3][4] , anti-cancer [5][6] , anti-inflammatory [7][8] , antituberculosis [9][10] , anti-bacterial [11][12] , antifungal [13][14] , anti-diabetic [15][16] , anti-microbial [17][18] , anticonvulsant 19 , cytotoxic [20][21] , antiproliferative 22 , anticandidal 23 , antiamoebic 24 activity, etc.…”

“…Imidazole and its derivatives involve one pot and the multicomponent reaction of substituted benzaldehyde, benzil, and ammonium acetate by using a PEG-SOCl as a green catalyst in aqueous media at room temperature or under microwave irradiation. The various synthetic methods have been developed for the synthesis of imidazole derivatives in the presence of different catalysts such as poly (4-vinylpyridine) supported TiCl 4 or [P 4 -VP]-Ti(IV) 25 , Amberlite IR 120H+ 26 , Appel reagent (Ph 3 P/CCl 4 ) 27 , Sulfonic Acid Magnetic Graphene Oxide (Fe3O4@GO-Pr-SO 3 H) 28 , Fly Ash Supported Bi 2 O 3 -ZnO 29 , Pyrrolidinium Hydrogen Sulfate (PHS) as the ionic liquid catalyst 30 , Pd/AlO(OH) NPs 31 , Urea/Hydrogen Peroxide (UHP) 32 , Nano-Zirconia (nano ZrO 2 ) 33 , Silver nanoparticles 34 , Copper Oxide nanoparticles 35 etc.…”