“…The multicomponent reactions have been recognized as a potent tool in synthetic organic chemistry as these reactions offer several fascinating advantages over multi-step processes such as minimal waste generation, less energy consumption, high atom economy, and time efficiency, thus complying with the goals of green and sustainable chemistry. [26][27][28][29][30][31][32][33] Additionally, in view of escalating environmental degradation due to the release of volatile and hazardous organic solvents, the use of green solvents, water in particular, is the pressing need to adopt benign synthetic routes in organic transformations. [34][35][36] 2-Amino-3-cyano-4H-chromene synthesized by multicomponent reactions of aryl aldehyde, dimedone, and malononitrile is one of the important structures in heterocyclic chemistry that has drawn considerable interest worldwide due to their favourable biological properties, such as anticancer, antibacterial, antimicrobial, and antiallergic (Fig.…”