Synthesis of indole-based ferulic acid derivatives and in vitro evaluation of antiviral activity against SARS-CoV-2

Verzola, Marina Mol S. A.; de Almeida Marques, Daisymara Priscila; da Silva, Elany Barbosa; Serafim, Mateus Sá Magalhães; Ferreira, Rafaela Salgado; Fajtová, Pavla; Kohlhoff, Markus; O’Donoghue, Anthony John; Maltarollo, Vinícius Gonçalves; Coelho-dos-Reis, Jordana Grazziela Alves; de Oliveira, Renata Barbosa

doi:10.1007/s00044-023-03134-7

Med Chem Res

2023

DOI: 10.1007/s00044-023-03134-7

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Synthesis of indole-based ferulic acid derivatives and in vitro evaluation of antiviral activity against SARS-CoV-2

Marina Mol S. A. Verzola,

Daisymara Priscila de Almeida Marques,

Elany Barbosa da Silva

et al.

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Cited by 3 publications

References 49 publications

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Recent report on indoles as a privileged anti-viral scaffold in drug discovery

Singh,

Bhutani,

Khanna

et al. 2025

European Journal of Medicinal Chemistry

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Recent report on indoles as a privileged anti-viral scaffold in drug discovery

Singh,

Bhutani,

Khanna

et al. 2025

European Journal of Medicinal Chemistry

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Bisindole Compounds—Synthesis and Medicinal Properties

Marinescu

2024

Antibiotics

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The indole nucleus stands out as a pharmacophore, among other aromatic heterocyclic compounds with remarkable therapeutic properties, such as benzimidazole, pyridine, quinoline, benzothiazole, and others. Moreover, a series of recent studies refer to strategies for the synthesis of bisindole derivatives, with various medicinal properties, such as antimicrobial, antiviral, anticancer, anti-Alzheimer, anti-inflammatory, antioxidant, antidiabetic, etc. Also, a series of natural bisindole compounds are mentioned in the literature for their various biological properties and as a starting point in the synthesis of other related bisindoles. Drawing from these data, we have proposed in this review to provide an overview of the synthesis techniques and medicinal qualities of the bisindolic compounds that have been mentioned in recent literature from 2010 to 2024 as well as their numerous uses in the chemistry of materials, nanomaterials, dyes, polymers, and corrosion inhibitors.

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Indole Derivatives: A Versatile Scaffold in Modern Drug Discovery—An Updated Review on Their Multifaceted Therapeutic Applications (2020–2024)

Mo,

Rao,

Kaur

et al. 2024

Molecules

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Indole derivatives have become an important class of compounds in medicinal chemistry, recognized for their wide-ranging biological activities and therapeutic potential. This review provides a comprehensive overview of recent advances in the evaluation of indole-based compounds in the last five years, highlighting their roles in cancer treatment, infectious disease management, anti-inflammatory therapies, metabolic disorder interventions, and neurodegenerative disease management. Indole derivatives have shown significant efficacy in targeting diverse biological pathways, making them valuable scaffolds in designing new drugs. Notably, these compounds have demonstrated the ability to combat drug-resistant cancer cells and pathogens, a significant breakthrough in the field, and offer promising therapeutic options for chronic diseases such as diabetes and hypertension. By summarizing recent key findings and exploring the underlying biological mechanisms, this review underscores the potential of indole derivatives in addressing major healthcare challenges, thereby instilling hope and optimism in the field of modern medicine.

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Synthesis of indole-based ferulic acid derivatives and in vitro evaluation of antiviral activity against SARS-CoV-2

Cited by 3 publications

References 49 publications

Recent report on indoles as a privileged anti-viral scaffold in drug discovery

Recent report on indoles as a privileged anti-viral scaffold in drug discovery

Bisindole Compounds—Synthesis and Medicinal Properties

Indole Derivatives: A Versatile Scaffold in Modern Drug Discovery—An Updated Review on Their Multifaceted Therapeutic Applications (2020–2024)

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