Synthesis of Indoles Derivatives Using Metal Free Catalyst in Organic Reactions

Das, Ratnesh; Dangi, Hemlata; Kashaw, Sushil K.

doi:10.33483/jfpau.873623

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…The base has two types: homogenous base 7 and heterogenous base 8 . Homogenous bases 9 , such as KOH, NaOH, and sodium-potassium methoxide, serve as effective catalysts, and heterogeneous bases are alkaline earth metal oxides 10 such as MgO, CaO SrO, zeolites, and KNO3 loaded on Al2O3.…”

Section: Introductionmentioning

confidence: 99%

One pot synthesis of some novel indole derivatives and their antimicrobial activity

et al. 2023

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<p>In this study, we describe the creation of a straightforward and incredibly effective protocol for the synthesis of new 3-Substituted indole derivatives. This multicomponent reaction involved indole, acetylacetone and active aldehyde derivatives in the presence of ethanol as solvent followed by acetonitrile as a base. We go through current developments in organic synthesis methodology for multicomponent reactions that produce substituted indole derivatives with a more environmentally friendly base catalytic condition, as well as the applications that go along with them. FT-IR, 1H-NMR and MS are used to characterise the synthesized compound of indole derivatives. Antibacterial activity of synthesized compounds has also been done. </p>

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Section: Introductionmentioning

confidence: 99%

One pot synthesis of some novel indole derivatives and their antimicrobial activity

et al. 2023

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Ru^II–Catalyzed C–H Activated Diverse Cyclization with Transformation of Substrate-DG to Functional Groups: Synthesis of Functionalized Indoles and Indenones

Baidya,

Khamarui,

Molla

et al. 2024

J. Org. Chem.

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We present an elegant and efficient method for Ru(II)-catalyzed C−H activation, followed by a diverse range of intermolecular cross-dehydrogenative coupling reactions. This process is facilitated by an intrinsic directing group (DG) and includes the in situ transformation of the DG into common and useful functional groups. Notably, this method avoids the installation and deinstallation of the directing group. Our approach enables the selective functionalization of benzimidate, coupled with the cyclization of o-alkynyl-aniline, resulting in the high-yield synthesis of diverse compounds such as indoles, and indenones. The sequential formation of C−N, C−C, and C−O bonds, followed by hydrolysis, underscores the versatile in situ transformation of the directing group. This work not only broadens the synthetic toolbox for constructing complex heterocyclic structures but also highlights the potential for sustainable and selective synthesis of valuable compounds.

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Indole-3-Carbinol Upconversion with Copper Oxide Nanoparticles Supported Graphitic Carbon Nitride: A Sustainable Approach

Rodrigues,

Varghese

2024

J. Electrochem. Soc.

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Electro-organic chemistry offers a sustainable and efficient approach to organic synthesis by utilizing electrochemical processes. This field has gained significant attention due to its potential for minimizing waste, reducing energy consumption, and enabling selective transformations. Herein, we report the development of a graphitic carbon nitride-coated carbon fiber electrode modified with electropolymerized amino-2-thiazole and electrodeposited Cu2O nanoparticles from copper nitrate trihydrate for the oxidation of Indole-3-carbinol (IC). Scanning electron microscopy, X-ray diffraction analysis, and X-ray photoelectron spectroscopy studies were carried out to characterize the developed electrode. Cyclic voltammetry, electrochemical impedance spectroscopy, and bulk electrolysis techniques were employed for the electrochemical studies. The enhanced electrochemical activity of the Cu2O-pAT-GCN-TCFP electrode compared to the individual GCN and polymer electrode was studied using electrochemical characterization, which revealed a 3-fold increase in the current response for Cu2O-pAT-GCN-TCFP (0.0011 A) compared to the bare electrode. The reaction was carried out using an aqueous carbonate buffer solution as an electrolyte via bulk electrolysis at a set potential of 0.82 V. The product obtained was isolated by column chromatography to obtain a yield of 74% and characterized by proton nuclear magnetic resonance (1H NMR) spectroscopy. Additionally, the Cu2O-pAT-GCN-TCFP electrode was studied for its stability, reproducibility, and selectivity.

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Synthesis of Indoles Derivatives Using Metal Free Catalyst in Organic Reactions

Cited by 3 publications

References 30 publications

One pot synthesis of some novel indole derivatives and their antimicrobial activity

One pot synthesis of some novel indole derivatives and their antimicrobial activity

Ru^II–Catalyzed C–H Activated Diverse Cyclization with Transformation of Substrate-DG to Functional Groups: Synthesis of Functionalized Indoles and Indenones

Indole-3-Carbinol Upconversion with Copper Oxide Nanoparticles Supported Graphitic Carbon Nitride: A Sustainable Approach

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Synthesis of Indoles Derivatives Using Metal Free Catalyst in Organic Reactions

Cited by 3 publications

References 30 publications

One pot synthesis of some novel indole derivatives and their antimicrobial activity

One pot synthesis of some novel indole derivatives and their antimicrobial activity

RuII–Catalyzed C–H Activated Diverse Cyclization with Transformation of Substrate-DG to Functional Groups: Synthesis of Functionalized Indoles and Indenones

Indole-3-Carbinol Upconversion with Copper Oxide Nanoparticles Supported Graphitic Carbon Nitride: A Sustainable Approach

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Ru^II–Catalyzed C–H Activated Diverse Cyclization with Transformation of Substrate-DG to Functional Groups: Synthesis of Functionalized Indoles and Indenones