Synthesis of inhibitors of glutamyl-tRNA synthetase

Desjardins, Michel; Desgagnés, Julie; Lacoste, Lucille; Yang, Fu De; Morin, Marie-Pascale; Lapointe, Jacques; Chênevert, Robert

doi:10.1016/s0960-894x(97)00434-4

Cited by 8 publications

(4 citation statements)

References 21 publications

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“…coli . Ester analogues prepared by Desjardins et al were also weak inhibitors of glutamyl tRNA synthetase …”

Section: Protein Synthesis Inhibitorsmentioning

confidence: 83%

“…219 Ester analogues prepared by Desjardins et al were also weak inhibitors of glutamyl tRNA synthetase. 220 To elucidate the substrate specificity of alanyl-tRNA synthetase, Ueda et al reported the synthesis and molecular conformation study, by X-ray single crystal analysis, of 5′-O-[N-(L-alanyl)sulfamoyl]adenosine (98), an analogue of 97a (Figure 51). 221 This research provided useful insights for analyzing the mechanism of specific amino acylation.…”

Section: ■ Protein Synthesis Inhibitorsmentioning

confidence: 91%

“…Several diadenosine-5'-tetraphosphate phosphonate analogues have been synthesised and proved to be moderate inhibitors of alanyl, lysyland phenyl alanyl tRNA synthetases from E Coli 219. Ester analogues prepared byDesjardins et al were also weak inhibitors of glutamyl tRNA synthetase 220.…”

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confidence: 99%

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Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant microorganisms. Numerous natural nucleosides and their synthetically modified analogues have been reported to have moderate to good antibiotic activity against different bacterial and fungal strains. Nucleoside-based compounds target several crucial processes of bacterial and fungal cells such as nucleoside metabolism and cell wall, nucleic acid, and protein biosynthesis. Nucleoside analogues have also been shown to target many other bacterial and fungal cellular processes although these are not well characterized and may therefore represent opportunities to discover new drugs with unique mechanisms of action. In this Perspective, we demonstrate that nucleoside analogues, cornerstones of anticancer and antiviral treatments, also have great potential to be repurposed as antibiotics so that an old drug can learn new tricks.

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