Synthesis of Ketoximino-Esters as Potential Ataraxics

Synthesis of ketoximino esters as antihistaminics

“…The addition product afforded the starting sulfa compound after being worked up. The use of other nonpolar solvents such as carbon tetrachloride (6-S), absolute The present investigation, however, is coiicerned with tlir syiithesis of sutne phosphorus coiiipuuiids viu the condensation of phosphorus tricliloride with ether (2- 4,9), and dry benzene (2, 9) which were used by otlier investigators proved ullsuitdble because sulfanilamide itself is insoluble in these sol--.…”

Synthesis of Ketoximino-Esters and -Ethers as Antihypertensive Agents

“…The compounds which were selected for synthesis are the oximino-esters and -ethers of 4,4'-bis(dimethy1amino) benzophenone and 4,4'-bis(diethylamino)benzophenone (Types I, 11, 111, and w. The Preparation of 12 new esters and ethers of Types I, Ir, 111, or Iv, starting with 4,4'-bis(dimethylamino) benzophenone and 44'-bis(diethylamin0) benzophenone, was accomplished by modifying the methods described in the literature (7)(8)(9). The reaction conditions were very critical in the formation of final products.…”