2021
DOI: 10.1002/cmdc.202100255
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Synthesis of L‐[5‐11C]Leucine and L‐α‐[5‐11C]Methylleucine via Pd0‐mediated 11C‐Methylation and Microfluidic Hydrogenation: Potentiality of Leucine PET Probes for Tumor Imaging

Abstract: The efficient synthesis of L-[5-11 C]leucine and L-α-[5-11 C] methylleucine has been investigated using a continuous twostep sequence of rapid reactions consisting of Pd 0 -mediated 11 C-methylation and microfluidic hydrogenation. The synthesis of L-[5-11 C]leucine and L-α-[5-11 C]methylleucine was accomplished within 40 min with a decay-corrected radiochemical yield of 15-38 % based on [ 11 C]CH 3 I, radiochemical purity of 95-99 %, and chemical purity of 95-99 %. The Pd impurities in the injectable solution … Show more

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