Synthesis of l-Ribose from d-Ribose by a Stereoconversion through Sequential Lactonization as the Key Transformation

Ban, Jaeyoung; Shabbir, Saira; Lim, Myung-Seop; Lee, Byunghoon; Rhee, Hakjune

doi:10.1055/s-0036-1588857

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Ribose (C 5 H 10 O 5 ), with a molecular weight of 150.13 Dalton, is a pentose sugar comprising two enantiomers: L-ribose and D-ribose. D-ribose, as the more stable form of the two enantiomers, serves as the predominant functional isoform found in all living cells [ 1 , 2 ]. D-ribose assumes a pivotal role as a constituent in various critical biomolecules, including RNA and nucleotides.…”

Section: Introductionmentioning

confidence: 99%

D-ribose metabolic disorder and diabetes mellitus

Tai,

Zhang,

Liu

et al. 2024

Mol Biol Rep

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D-ribose, an ubiquitous pentose compound found in all living cells, serves as a vital constituent of numerous essential biomolecules, including RNA, nucleotides, and riboflavin. It plays a crucial role in various fundamental life processes. Within the cellular milieu, exogenously supplied D-ribose can undergo phosphorylation to yield ribose-5-phosphate (R-5-P). This R-5-P compound serves a dual purpose: it not only contributes to adenosine triphosphate (ATP) production through the nonoxidative phase of the pentose phosphate pathway (PPP) but also participates in nucleotide synthesis. Consequently, D-ribose is employed both as a therapeutic agent for enhancing cardiac function in heart failure patients and as a remedy for post-exercise fatigue. Nevertheless, recent clinical studies have suggested a potential link between D-ribose metabolic disturbances and type 2 diabetes mellitus (T2DM) along with its associated complications. Additionally, certain in vitro experiments have indicated that exogenous D-ribose exposure could trigger apoptosis in specific cell lines. This article comprehensively reviews the current advancements in D-ribose’s digestion, absorption, transmembrane transport, intracellular metabolic pathways, impact on cellular behaviour, and elevated levels in diabetes mellitus. It also identifies areas requiring further investigation.

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Section: Introductionmentioning

confidence: 99%

D-ribose metabolic disorder and diabetes mellitus

Tai,

Zhang,

Liu

et al. 2024

Mol Biol Rep

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“…It can promote the growth of intestinal probiotics and is used for the synthesis of the anti-tumor and immunostimulating drugs (Korneeva et al 2012; Ranta et al 2012; Zhang et al 2017). Therefore, the synthesis of l -ribose and d -mannose was urgently demanded in industry (Beerens et al 2012; Ban et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Characterization of a d-lyxose isomerase from Bacillus velezensis and its application for the production of d-mannose and l-ribose

2019

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d-Mannose and l-ribose are two important monosaccharides, which have attracted public attention recently because of their great application potentials in food, cosmetic and pharmaceutical industries. Sugar isomerases catalyze the sugar isomerization and therefore can be used as the biocatalysts for production of the high-value sugars from inexpensive sugars. l-arabinose isomerase catalyzes the conversion of l-arabinose to l-ribulose, while d-lyxose isomerase catalyzes l-ribulose and d-fructose to l-ribose and d-mannose, respectively. In this paper, a putative d-LI from Bacillus velezensis (BvLI) was identified, characterized and used to produce d-mannose and l-ribose from d-fructose and l-arabinose, respectively. The recombinant BvLI exhibited a maximum activity at 55 °C and pH 6.5, in the presence of 0.1 mM Co2+. Approximately 110.75 g/L d-mannose was obtained from 500 g/L d-fructose in 6 h by the recombinant BvLI, and approximately 105 g/L l-ribose was obtained from 500 g/L l-arabinose in 8 h by the successive biocatalysis of l-arabinose isomerase from Bacillus licheniformis (BlAI) and BvLI.

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2020

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Synthesis of l-Ribose from d-Ribose by a Stereoconversion through Sequential Lactonization as the Key Transformation

Cited by 4 publications

References 17 publications

D-ribose metabolic disorder and diabetes mellitus

D-ribose metabolic disorder and diabetes mellitus

Characterization of a d-lyxose isomerase from Bacillus velezensis and its application for the production of d-mannose and l-ribose

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