Synthesis of licochalcone analogues with increased anti-inflammatory activity

Kim, Sijun; Kim, Cheol Gi; Yun, So-Ra; Kim, Jin‐Kyung; Jun, Jong‐Gab

doi:10.1016/j.bmcl.2013.11.044

Cited by 26 publications

(15 citation statements)

References 17 publications

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“…Several compounds of chalcones were discovered to strongly inhibit nitric oxide (NO), IL-6, and prostaglandin E 2 (PGE 2 ) secretion. On one hand, echinatin, licochalcones A-E, isobavachalcone, morachalcone A, DTM, licoagrochalcone C, and 4-hydroxylonchocarpin have been demonstrated to show significant inhibitory activity on LPSinduced NO production [10,21,69,70,78,80]. On the other hand, these compounds also have other different anti-inflammatory mechanisms.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Natural Chalcones in Chinese Materia Medica: Licorice

Wang

Liang

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Licorice is an important Chinese materia medica frequently used in clinical practice, which contains more than 20 triterpenoids and 300 flavonoids. Chalcone, one of the major classes of flavonoid, has a variety of biological activities and is widely distributed in nature. To date, about 42 chalcones have been isolated and identified from licorice. These chalcones play a pivotal role when licorice exerts its pharmacological effects. According to the research reports, these compounds have a wide range of biological activities, containing anticancer, anti-inflammatory, antimicrobial, antioxidative, antiviral, antidiabetic, antidepressive, hepatoprotective activities, and so on. This review aims to summarize structures and biological activities of chalcones from licorice. We hope that this work can provide a theoretical basis for the further studies of chalcones from licorice.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Natural Chalcones in Chinese Materia Medica: Licorice

Wang

Liang

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…DDP was synthesized as previously described [14]. LPS derived from Escherichia coli (0111:B4), dimethylsulfoxide (DMSO), and G418 were obtained from Sigma-Aldrich (St Louis, MO, USA).…”

Section: Reagentsmentioning

confidence: 99%

“…(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one (DDP) markedly suppresses LPS-induced NO in RAW 264.7 macrophages [14]. DDP is a novel licochalcone B derivative which has 3,4-dihydroxy-2-methoxy substituent and a resorcinol type ring A.…”

Section: Introductionmentioning

confidence: 99%

(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one, a novel licochalcone B derivative compound, suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice

Park

Jun

Kim

2014

Chemico-Biological Interactions

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“…Licochalcones, echinatin, and isoliquiritigenin are the major active components extracted from licorice [6]. These compounds belong to flavonoids that have various pharmacological activities [7][8][9].…”

Section: Introductionmentioning

confidence: 99%