Synthesis of Lipophilic Core–Shell Fe3O4@SiO2@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance–Photoacoustic Dual Imaging

Monaco, Ilaria; Arena, Francesca; Biffi, Stefania; Locatelli, Erica; Bortot, Barbara; Cava, Francesca La; Marini, Giada M.; Severini, Giovanni Maria; Terreno, Enzo; Franchini, Mauro Comes

doi:10.1021/acs.bioconjchem.7b00076

Cited by 65 publications

(47 citation statements)

References 25 publications

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“…To enhance the advantageous plasmonic properties of AuNPs, AuNP composites with other metals and metal oxides have been prepared and investigated in diverse applications. [39][40][41][42][43][44][45] The primary purpose of designing this composite is to enable the magnetic delivery of AuNPs to the target tissues, where PPTT can enhance the thermal release by the PVA network by incorporating AuNPs into nanocomposite materials with Fe 3 O 4 NPs via AuS bonding. [27] Herein, for the nanocomposite therapeutic design in this work, the PVA ability to incorporate and release DXL was combined with the functionalities of gold and iron oxide NPs to create Au/Fe 3 O 4 /PVA-10%DXL.…”

Section: Different Composites Of Fe 3 O 4 Andmentioning

confidence: 99%

“…The composite system that has been studied the most for cancer treatment is one that integrates the gold and iron oxide. [39][40][41][42][43][44] In general, gold nanoparticles (AuNPs) represent an important class of anticancer agents due to their significant role in the inhibition of tumor metastasis, photodynamic [28] and plasmonic photothermal therapy (PPTT). [29,30] Specifically, unique plasmonic properties of AuNPs, that can be tailored in the designed nanocomposites, play an important role in controlling and modulating drug release inside the tumor cells.…”

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Taheri‐Ledari

Zhang

Radmanesh

et al. 2020

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101

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To further improve the efficiencies of the established drugs, various treatment strategies, such as preparation of protein-drug conjugates and the design of nanoscale drug-carriers, are used to increase the efficacy of therapeutic agents. [6-8] Several effective nanocarrier systems were designed to deliver anti-cancer cytotoxic agents to tumor cells with high selectivity and efficacy while minimizing negative side effects. [9,10] Drug nano-carriers provide multiple advantages, such as convenient uptake and internalization, reduced drug interactions, optimized lifetime, and widened therapeutic windows. [11] In this regard, the synthetic design and applications of different types of iron oxide nanoparticles (Fe 3 O 4 NPs) have received significant attention since these NPs can be magnetically directed inside target tissues and their surface can be easily functionalized with diverse polymers and organic compounds. [12-16] Previously, we have reported several magnetic systems in micro-and nanoscale for diverse functional applications. [17-24] To further expand upon this work, we utilized one of the most commonly employed polymers, polyvinyl alcohol (PVA), to encapsulate magnetic Fe 3 O 4 NPs by virtue of its extended hydrogen bonding and to provide a selective release medium for DXL. [25] Drug molecules, such as DXL, can be incorporated into a PVA gel when polymer chains are in a shrunk state at low temperatures, and subsequently released in a target tissue upon a PVA transition into a swollen gel at 37 °C. [26] PVA features several important advantages. First is the ability to form a gel owing to multiple hydrogen bonding by OH groups. A versatile breast cancer-targeting nanocomposite therapeutic combining docetaxel (DXL), polyvinyl alcohol (PVA) network for controlled release, and silica-protected magnetic iron oxide nanoparticles (Fe 3 O 4 NPs) for targeted delivery and gold nanoparticles (AuNPs) for plasmonic photothermal therapy (PPTT) is presented in this work. First, the designed nanocomposite is magnetically directed for cancer-targeted therapy confirmed by computerized tomography (CT) scans. Second, 10% DXL by mass is loaded into PVA, a pH and temperature responsive gel, for controlled release. Third, PPTT is confirmed with Au/Fe 3 O 4 /PVA-10%DXL using a prototype circulation system and then for tumor treatment in vivo; Au/Fe 3 O 4 /PVA-10%DXL is conveniently directed and the entrapped DXL is selectively released (≈96%) via the interaction of green and near-infrared (NIR) light with the localized surface plasmon resonance of AuNPs. A 75% cell death is reported from in vitro studies with DXL doses as low as 20 µg mL −1 of Au/Fe 3 O 4 /PVA-10%DXL, and a 70% tumor growth inhibition is demonstrated by in vivo experiments with the biosafety studies confirming minimal side effects to other organs. Overall, the developed Au/Fe 3 O 4 /PVA-10%DXL has a strong potential to simultaneously enhance CT imaging contrast together with the targeted delivery of DXL.

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Section: Different Composites Of Fe 3 O 4 Andmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

RETRACTED: Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Taheri‐Ledari

Zhang

Radmanesh

et al. 2020

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101

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“…The surface of the probes is composed of targeting moieties, such as antibodies, peptides, and small-molecule ligands that can bind with high affinity and specificity for overexpressed receptors, thus enabling the cellular and molecular imaging of cancer. Several targeted PA agents have been developed, based on functionalization with antibodies [ 16 , 70 , 71 ], peptides [ 72 , 73 ], or small molecules [ 28 , 74 , 75 ]. Owing to the presence of quinine groups in the melanin structure, simple modification of the melanin particle is feasible by reaction with thiols or amines via Michael addition or Schiff base reactions, enabling the introduction of targeting moieties [ 45 ].…”

Section: Targeted Melanin-based Probesmentioning

confidence: 99%

“…Such a class of probes is extremely useful in detecting and delineating tumors, as well as in assessing tumor vasculature properties, such as permeability and vascular volume. Other contrast agents can be conjugated to molecular moieties (such as peptides or antibodies), providing active targeting capabilities, or be loaded with a drug, acting as drug carriers, or being exploited as therapeutic agents [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications

Longo

Stefanìa

Aime

et al. 2017

IJMS

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Optoacoustic imaging emerged in early 1990s as a new biomedical imaging technology that generates images by illuminating tissues with short laser pulses and detecting resulting ultrasound waves. This technique takes advantage of the spectroscopic approach to molecular imaging, and delivers high-resolution images in the depth of tissue. Resolution of the optoacoustic imaging is scalable, so that biomedical systems from cellular organelles to large organs can be visualized and, more importantly, characterized based on their optical absorption coefficient, which is proportional to the concentration of absorbing chromophores. Optoacoustic imaging was shown to be useful in both preclinical research using small animal models and in clinical applications. Applications in the field of molecular imaging offer abundant opportunities for the development of highly specific and effective contrast agents for quantitative optoacoustic imaging. Recent efforts are being made in the direction of nontoxic biodegradable contrast agents (such as nanoparticles made of melanin) that are potentially applicable in clinical optoacoustic imaging. In order to increase the efficiency and specificity of contrast agents and probes, they need to be made smart and capable of controlled accumulation in the target cells. This review was written in recognition of the potential breakthroughs in medical optoacoustic imaging that can be enabled by efficient and nontoxic melanin-based optoacoustic contrast agents.

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“…The systematic combination of different anticancer treatments can overcome drawbacks of individual methods to improve the efficiency of treatment . With the development of nanotechnology, some nanocomposites have attracted increasing attention in nanomedicine owing to their advanced physical, chemical, and biological properties .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of a GNRs@mSiO₂‐ICG‐DOX@Se‐Se‐FA Nanocomposite for Controlled Chemo‐/Photothermal/Photodynamic Therapy

Lin

2018

Eur J Inorg Chem

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A novel GNRs@mSiO 2 core-shell nanocomposite has been synthesized to integrate sensitive chemotherapy with photodynamic therapy (PDT) and photothermal therapy (PTT) for enhanced antitumor treatment by using gold nanorods (GNRs) as the core and mesoporous silica (mSiO 2 ) as the shell. After modifying with -NH 2 , Indocyanine Green (ICG, negative charge) and doxorubicin hydrochloride (DOX, positive charge) molecules could be stored in the mesopores by the layer-bylayer assembly method through electrostatic interactions. To inhibit leakage from the mesopores, a sensitive Se-Se linker was synthesized and adopted as a nanovalve coated on the outside of the nanoparticles (GNRs@mSiO 2 -ICG-DOX@Se-Se). Under NIR (808 nm) irradiation, heat elevation (derived from GNR/ICG) and generation of reactive oxygen species (ROS, derived from ICG) [a] 4375 Scheme 1. Schematic illustration of the synthesis of NIR-sensitive nanocomposites and the chemotherapy, PDT and PTT process. 4376 Figure 5. (A) UV/Vis spectra of DPBF after irradiation of GNRs@mSiO 2 -ICG2 with 808 nm NIR (2 W cm -2 ) for 0-80 min and (B) the decay curves of DPBF absorbance at 407 nm in solutions of different nanoparticle samples as a function of irradiation time.

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Synthesis of Lipophilic Core–Shell Fe₃O₄@SiO₂@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance–Photoacoustic Dual Imaging

Cited by 65 publications

References 25 publications

RETRACTED: Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

RETRACTED: Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications

Synthesis of a GNRs@mSiO₂‐ICG‐DOX@Se‐Se‐FA Nanocomposite for Controlled Chemo‐/Photothermal/Photodynamic Therapy

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Synthesis of Lipophilic Core–Shell Fe3O4@SiO2@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance–Photoacoustic Dual Imaging

Cited by 65 publications

References 25 publications

RETRACTED: Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

RETRACTED: Multi‐Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor

Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications

Synthesis of a GNRs@mSiO2‐ICG‐DOX@Se‐Se‐FA Nanocomposite for Controlled Chemo‐/Photothermal/Photodynamic Therapy

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Product

Resources

About

Synthesis of Lipophilic Core–Shell Fe₃O₄@SiO₂@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance–Photoacoustic Dual Imaging

Synthesis of a GNRs@mSiO₂‐ICG‐DOX@Se‐Se‐FA Nanocomposite for Controlled Chemo‐/Photothermal/Photodynamic Therapy