Synthesis of lipophosphoramidyl-cyclodextrins and their supramolecular properties

Cyclodextrin nanoassemblies: a promising tool for drug delivery

“…Furthermore, chain length did not affect vesicle size but only bilayer thickness [41,42]. Sometimes the hydration of a lipid film can be used to prepare NPs without an aqueous core, probably as nanospheres [40]. The solvent injection technique leads to monodispersed [43] and rather small NPs [23].…”

“…the diameter) of NPs. A few techniques have been used to prepare NPs with amphiphilic CDs including the solvent displacement technique [27], nanoprecipitation [39] and hydration of a lipid film [40]. Some vesicles [21] were prepared by hydration of a lipid film followed by dilution, extrusion or sonication.…”

Cyclodextrin-based star polymers as a versatile platform for nanochemotherapeutics: Enhanced entrapment and uptake of idarubicin

“…In a similar study, amphiphilic lipophosphoramidyl-CD nanoparticles encapsulating carboxyfluorescein were prepared; the encapsulation efficiency was 42% [12]. …”

“…The 21-substitutable hydroxyl groups on the peripheral surface of ␤-CD provide the possibility to produce functionalized ␤-CDs like star-shaped polymers. A variety of chemical approaches have been exploited for grafting hydrophobic arms on CD rim including nucleophilic substitution 'click chemistry' [11], Atherton-Todd reaction [12] and Atom Transfer Radical Polymerization (ATRP) [6]. For detailed reaction mechanisms, refer to Kamigaito et al [13].…”

Atherton–Todd reaction: mechanism, scope and applications

“…β-Cyclodextrin (β-CD) is another molecular platform that was chemically modified with a lipid moiety introduced by an AT reaction [138]. As exemplified in Scheme 43, Djedaïni-Pilard et al reported the use of the AT reaction to introduce a lipophosphoramidate fragment on a permethylated β-cyclodextrin possessing one primary amine (Scheme 43-i).…”