Synthesis of low-molecular-weight gel with tunable gel-sol transition temperature for thermo-sensitive drug controlled release

Wei, Yy.; Feng, Xin Jiang; Liu, Miaochang; Huang, Xiaobo; Gao, Wenxia; Wu, Haixia

doi:10.1016/j.molstruc.2022.133212

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Stimulus-responsive hydrogel diabetic wound dressing can achieve an on-demand release of drugs by absorbing wound exudate or changing its phase and volume in response to changes in the wound microenvironment, and can also achieve on-demand removal of diabetic wound dressings [10,11]. Thermo-sensitive bio-hydrogels in diabetic Gels 2023, 9, 987 2 of 14 wound dressing are one of these smart hydrogels which can respond to changes in external ambient temperature without any chemical treatment of the internal structure [12,13]. Such bio-hydrogels can modulate and regulate feedback control of drug release.…”

Section: Introductionmentioning

confidence: 99%

Wound Microenvironment Self-Adjusting Hydrogels with Thermo-Sensitivity for Promoting Diabetic Wound Healing

Li,

Guo,

Wang

et al. 2023

Gels

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The hard-healing chronic wounds of diabetics are still one of the most intractable problems in clinical skin injury repair. Wound microenvironments directly affect wound healing speed, but conventional dressings exhibit limited efficacy in regulating the wound microenvironment and facilitating healing. To address this serious issue, we designed a thermo-sensitive drug-controlled hydrogel with wound self-adjusting effects, consisting of a sodium alginate (SA), Antheraeapernyi silk gland protein (ASGP) and poly(N-isopropylacrylamide) (PNIPAM) for a self-adjusting microenvironment, resulting in an intelligent releasing drug which promotes skin regeneration. PNIPAM has a benign temperature-sensitive effect. The contraction, drugs and water molecules expulsion of hydrogel were generated upon surpassing lower critical solution temperatures, which made the hydrogel system have smart drug release properties. The addition of ASGP further improves the biocompatibility and endows the thermo-sensitive drug-controlled hydrogel with adhesion. Additionally, in vitro assays demonstrate that the thermo-sensitive drug-controlled hydrogels have good biocompatibility, including the ability to promote the adhesion and proliferation of human skin fibroblast cells. This work proposes an approach for smart drug-controlled hydrogels with a thermo response to promote wound healing by self-adjusting the wound microenvironment.

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