Synthesis of macromolecular systems via lipase catalyzed biocatalytic reactions: applications and future perspectives

Kumar, Amit; Khan, Abdullah; Malhotra, Shashwat; Mosurkal, Ravi; Dhawan, Ashish; Pandey, Mukesh K.; Singh, Brajendra K.; Kumar, Rajesh; Prasad, Ashok K.; Sharma, Sunil K.; Samuelson, Lynne A.; Cholli, Ashok L.; Len, Christophe; Richards, Nigel G. J.; Kumar, Jayant; Haag, Rainer; Watterson, Arthur C.; Parmar, Virinder S.

doi:10.1039/c6cs00147e

Cited by 43 publications

(17 citation statements)

References 152 publications

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“…Most lipases belong to the α/β-hydrolase superfamily, which is supposed to have a reaction mechanism similar to that of serine proteases [5,6]. In addition to their physiological roles, lipases are highly useful for industrial applications in dairy, food, pharmaceutical, cosmetic, biofuel, and fine chemical industries owing to their high stability, broad substrate specificity, high regio-/stereo-selectivity, and remarkable stability [7][8][9]. Moreover, there are still great demands for new lipases with great stability, high selectivity, and strong activity, which could be applied to a wide range of industrial processes.…”

Section: Introductionmentioning

confidence: 99%

Bacterial Hormone-Sensitive Lipases (bHSLs): Emerging Enzymes for Biotechnological Applications

Kim

2017

Journal of Microbiology and Biotechnology

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Lipases are important enzymes with biotechnological applications in dairy, detergent, food, fine chemicals, and pharmaceutical industries. Specifically, hormone-sensitive lipase (HSL) is an intracellular lipase that can be stimulated by several hormones, such as catecholamine, glucagon, and adrenocorticotropic hormone. Bacterial hormone-sensitive lipases (bHSLs), which are homologous to the C-terminal domain of HSL, have α/β-hydrolase fold with a catalytic triad composed of His, Asp, and Ser. These bHSLs could be used for a wide variety of industrial applications because of their high activity, broad substrate specificity, and remarkable stability. In this review, the relationships among HSLs, the microbiological origins, the crystal structures, and the biotechnological properties of bHSLs are summarized.

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Section: Introductionmentioning

confidence: 99%

Bacterial Hormone-Sensitive Lipases (bHSLs): Emerging Enzymes for Biotechnological Applications

Kim

2017

Journal of Microbiology and Biotechnology

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“…Herein, the authors employed an additional diarylboronic acid catalyst to form preferentially glycerol-derived linear polyester. Besides, it is well known that enzymatic controlled polymerization of glycerol is more or less able to generate linear and branched polyesters [35,36,37]. In order to produce the corresponding the tetrahydroxylated prepolymer BDHPFDC, our preceding procedure was applied at 160 °C for 13 h. Similarly, the batch microwave radiation permitted us to reduce the reaction time (2 h vs. 13 h) and the temperature (150 °C vs. 160 °C) with the synthesis of BDHPFDC in 80% yield (Scheme 4).…”

Section: Resultsmentioning

confidence: 99%

One-Pot FDCA Diester Synthesis from Mucic Acid and Their Solvent-Free Regioselective Polytransesterification for Production of Glycerol-Based Furanic Polyesters

2019

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A one pot-two step procedure for the synthesis of diethyl furan-2,5-dicarboxylate (DEFDC) starting from mucic acid without isolation of the intermediate furan dicarboxylic acid (FDCA) was studied. Then, the production of three different kinds of furan-based polyesters— polyethylene-2,5-furan dicarboxylate (PEF), polyhydropropyl-2,5-furan dicarboxylate(PHPF) and polydiglycerol-2,5-furandicarboxylate (PDGF)—was realized through a Co(Ac)2·4H2O catalyzed polytransesterification performed at 160 °C between DEFDC and a defined diol furan-based prepolymer or pure diglycerol. In parallel to polymerization process, an unattended regioselective 1-OH acylation of glycerol by direct microwave-heated FDCA diester transesterification led to the formation of a symmetric prepolymer ready for further polymerization and clearly identified by 2D NMR sequences. Furthermore, the synthesis of a more soluble and hydrophilic diglycerol-based furanic polyester was also achieved. The resulting biobased polymers were characterized by NMR, FT-IR spectroscopy, DSC, TGA and XRD. The morphologies of the resulted polymers were observed by FE-SEM and the purity of the material by EDX.

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“…Finally, we conclude with remarks on the recent developments, lessons learned and the future applications. For detailed account of other types of amphiphiles such as polymeric, dendritic and small ionic ones, we recommend review articles by Sorrenti et al, 11 Rosen et al, 17 Thota et al, 18 and Parmar et al 19,20…”

Section: Amphiphiles and Self-assemblymentioning

confidence: 99%

Non-ionic small amphiphile based nanostructures for biomedical applications

et al. 2020

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Synthesis of macromolecular systems via lipase catalyzed biocatalytic reactions: applications and future perspectives

Abstract: This review highlights the application of lipases in the synthesis of pharmaceutically important small molecules and polymers for diverse applications.

Cited by 43 publications

References 152 publications

Bacterial Hormone-Sensitive Lipases (bHSLs): Emerging Enzymes for Biotechnological Applications

Bacterial Hormone-Sensitive Lipases (bHSLs): Emerging Enzymes for Biotechnological Applications

One-Pot FDCA Diester Synthesis from Mucic Acid and Their Solvent-Free Regioselective Polytransesterification for Production of Glycerol-Based Furanic Polyesters

Non-ionic small amphiphile based nanostructures for biomedical applications

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