Synthesis of Manganese Complexes of 4,5-Dihydropyrazoles and Metalation Effect on the Antimicrobial Activity

Abstract

1-Acetyl-5-aryl-3-(substituted thienyl)-4,5-dihydropyrazoles and their manganese complexes have been synthesized and characterized on the basis of elemental analysis, magnetic susceptibility, molar conductance, molecular weight determination and spectroscopic data. The IR data indicated that the coordination of the ligands to the manganese (II) ion was through the azomethine nitrogen and carbonyl oxygen. The micro analytical, electronic spectral assignments and magnetic moment suggested an octahedral geometry around the metal ion with 1:2 metal ligand stoichiometry. The complexes exhibited in vitro microbiocidal activity in comparison to ligands.