Synthesis of mesoporous core-shell structured GdPO4:Eu@SiO2@mSiO2 nanorods for drug delivery and cell imaging applications

Wu, Yanli; Xu, Xiumei; You, Xiu-Li; Xiao, Qiang

doi:10.1016/j.jre.2020.01.008

Cited by 14 publications

(6 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The absorption peaks at 622 cm −1 and 545 cm −1 were caused by the O-P-O bending vibration and represent the characteristic absorption of PO4 3− . Thus, the amorphous SiO2 shell coating on the surface of GdPO4‧H2O nanobunches was confirmed in terms of chemical composition [32]. With silane coupling agent (APS) pre-modification and further polyglutamic acid grafting, the absorption peaks at 1549 cm −1 , 1654 cm −1 and 1737 cm −1 in Figure 5B-E were progressively enhanced with increasing ratios of GdPO4•H2O@SiO2-APS:NCA = 1:0.125 (B), 1:0.25 (C), 1:0.5 (D) and 1:1 (E) as they are attributed to the stretching vibrational absorption peak of amide N-H, amide C=O and carboxy C=O, respectively, demonstrating the presence of PBLG chains on the surface of GdPO4‧H2O [33].…”

Section: Further Surface Modification Of Gdpomentioning

confidence: 68%

“…At this time, the OD values of the GdPO 4 •H 2 O/PLGA, GdPO 4 •H 2 O@SiO 2 /PLGA, GdPO 4 •H 2 O@SiO 2 -APS/PLGA and PBLGg-GdPO 4 •H 2 O/PLGA groups were all higher than those of PLGA, especially the OD values of PBLG-g-GdPO 4 •H 2 O/PLGA cultured cells, which were the highest, with significant differences (p < 0.05). This indicates that the modifiers had good biocompatibility, which may have been the consequence of the positive biocompatibility and biological effects of GdPO 4 •H 2 O, SiO 2 , APS and polyglutamic acid in PBLG [32,[41][42][43][44]. At 7 days of incubation, the OD values of the groups were similar, with only the GdPO 4 •H 2 O@SiO 2 /PLGA and PBLG-g-GdPO 4 •H 2 O/PLGA groups having slightly higher OD values than the glass, GdPO 4 •H 2 O/PLGA and GdPO 4 •H 2 O@SiO 2 -APS/PLGA groups, but there was no significant difference (p > 0.05).…”

Section: Cellular Response 241 Cytotoxicity and Biocompatibilitymentioning

confidence: 94%

“…There was no significant difference in XRD for GdPO 4 •H 2 O@SiO 2 (A) and PBLG-g-GdPO 4 •H 2 O with the ratios of GdPO 4 •H 2 O@SiO 2 -APS:NCA = 1:0.125 (B), 1:0.25 (C). This was mainly due to the fact that with the amorphous structure and thinner shell layer SiO 2 encapsulation, no characteristic peak of the silicon shell was observed [32]. Moreover, the fewer NCA involved in the grafting reaction the less PBLG will be grafted to the surface of GdPO 4 •H 2 O@SiO 2 , producing a thinner surface modification layer and therefore have no affect on the XRD.…”

Section: Further Surface Modification Of Gdpo4‧h2o@sio2 With Polymer ...mentioning

confidence: 99%

“…At this time, th OD values of the GdPO4·H2O/PLGA, GdPO4•H2O@SiO2/PLGA, GdPO4‧H2O@SiO APS/PLGA and PBLG-g-GdPO4•H2O/PLGA groups were all higher than those of PLGA especially the OD values of PBLG-g-GdPO4•H2O/PLGA cultured cells, which were th highest, with significant differences (p < 0.05). This indicates that the modifiers had goo biocompatibility, which may have been the consequence of the positive biocompatibili and biological effects of GdPO4‧H2O, SiO2, APS and polyglutamic acid in PBLG [32,[41][42][43][44] At 7 days of incubation, the OD values of the groups were similar, with only th GdPO4•H2O@SiO2/PLGA and PBLG-g-GdPO4•H2O/PLGA groups having slightly high OD values than the glass, GdPO4·H2O/PLGA and GdPO4‧H2O@SiO2-APS/PLGA group but there was no significant difference (p > 0.05). In the above cell experiments, it w demonstrated that the surface modification of GdPO4·H2O resulted in low toxicity of th modifiers to MC3T3-E1 cells in the experimental concentration range and in PLGA, wi no significant inhibition of cell adhesion behavior and cell proliferation, but rather a pr cell proliferation effect at 3 days of culture (notably PBLG-g-GdPO4•H2O), indicating th the modifiers were all biocompatible.…”

Section: Cellular Response 241 Cytotoxicity and Biocompatibilitymentioning

confidence: 99%

See 3 more Smart Citations

Surface Biofunctionalization of Gadolinium Phosphate Nanobunches for Boosting Osteogenesis/Chondrogenesis Differentiation

Cai

Guo

Yang

et al. 2023

IJMS

View full text Add to dashboard Cite

In order to achieve smart biomedical micro/nanomaterials, promote interaction with biomolecules, improve osteogenic/chondrogenic differentiation, exhibit better dispersion in bone implants and ultimately maximize functionality, we innovatively and successfully designed and synthesized polymer PBLG-modified GdPO4‧H2O nanobunches by hydroxylation, silylation and glutamylation processes. The effects of different feeding ratios on the surface coating of GdPO4‧H2O with Si-OH, the grafting γ-aminopropyltriethoxysilane (APS) and the in situ ring-opening polymerization reaction of poly(g-benzyl-L-glutamate) (PBLG) were investigated, and the physical and chemical properties were characterized in detail. When GdPO4‧H2O@SiO2–APS:NCA = 4:1, the PBLG-g-GdPO4‧H2O grafting rate was 5.93%, with good stability and dispersion in degradable polymeric materials. However, the MRI imaging signal was sequentially weakened as the modification process proceeded. Despite this, the biological effects had surprising findings. All the modifiers at appropriate concentrations were biocompatible and biologically active and the biomacromolecules of COL I and COL II in particular were expressed at least 3 times higher in GdPO4‧H2O@SiO2 compared to the PLGA. This indicates that the appropriate surface modification and functionalization of gadolinium-containing micro/nanomaterials can promote interaction with cells and encourage bone regeneration by regulating biomacromolecules and can be used in the field of biomedical materials.

show abstract

Section: Further Surface Modification Of Gdpomentioning

confidence: 68%

Section: Cellular Response 241 Cytotoxicity and Biocompatibilitymentioning

confidence: 94%

Section: Further Surface Modification Of Gdpo4‧h2o@sio2 With Polymer ...mentioning

confidence: 99%

Section: Cellular Response 241 Cytotoxicity and Biocompatibilitymentioning

confidence: 99%

See 2 more Smart Citations

Surface Biofunctionalization of Gadolinium Phosphate Nanobunches for Boosting Osteogenesis/Chondrogenesis Differentiation

Cai

Guo

Yang

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Trong những thập niên gần đây, công nghê nano đóng vai trò rất quan trọng trong một số lĩnh vực như quang xúc tác, thiết bị hiển thị, pin năng lượng mặt trời, dẫn truyền thuốc, công nghệ LED [1][2][3][4][5][6]. Trong đó, GdPO 4 pha tạp ion đất hiếm là một số những vật liệu được nghiên cứu rất nhiều vì GdPO 4 là mạng nền có độ ổn định về nhiệt và hóa học cao.…”

Section: Giới Thiệu Chungunclassified

Synthesis & PL study of GdPO4:Tb,Eu nanophosphor

Dieu¹,

Duc²,

Duc³

et al. 2021

vietnam j. catal. adsorpt.

View full text Add to dashboard Cite

Tb3+ and Eu3+ ions co-doped containing monoclinic GdPO4 nanocrystals were successfully obtained by a straightforward combustion method. The crystal structure and optical characteristics were investigated by methods: XRD, photoluminescence spectra (PL). The XRD result indicates the GdPO4:10%Tb, x%Eu had monoclinic phase and the average particle size was about 10 nm. Under excitation wavelength at 394 nm, photoluminescent emission spectra of GdPO4:10%Tb, x%Eu nanopowders show strong characteristic emission of Eu3+ ions and no characteristic emission of Tb3+ ions was found. However, under the excitation of 273 nm or 368 nm, the emission spectra of the samples were shown characteristic emission of Tb3+ ions with 5D4 - 7FJ (J=3-6) transitions and Eu3+ ions with 5D0-7FJ (J=0-4) transitions.

show abstract

Rod-shaped hollow mesoporous silica drug delivery system: synthetic design, ibuprofen delivery, and optical imaging

Wu,

Guan,

et al. 2024

Chem. Pap.

Self Cite

View full text Add to dashboard Cite

In this work, a multifunctional drug delivery system (DDS) composed of mesoporous hollow silica nanorod core and luminescent Gd 2 O 3 :Eu shell (MHSNR@Gd 2 O 3 :Eu) was fabricated and applied for optical imaging and drug carrying. The formation process, phase and morphology of the DDS were investigated. The results show that the multifunctional DDS possess uniform core-shell hollow structure, in which the core length of the hollow silica nanorods as approximately 400 nm and a width of approximately 150 nm and the Gd 2 O 3 :Eu shell was approximately 30 nm thick. Due to the doping of the Eu 3+ , the as prepared MHSNR@Gd 2 O 3 :Eu emitted bright red light. The in vitro assays with NCI-H460 lung cancer cells domenstrated that the as-obtained MHSNR@Gd 2 O 3 :Eu could rapidly and massively enter the cell. Using ibuprofen as a model drug, the release process of the synthesized MHSNR@Gd 2 O 3 :Eu was monitored in-vitro. In particular, as the amount of ibuprofen released increases, the photoluminescence intensity of DDS increases. Thus it is possible to monitor and track the release process through changes in luminous intensity. In summary, it is expected that MHSNR@Gd 2 O 3 :Eu may be applied in drug carrying, luminescent tracking and monitoring, and optical imaging. Furthermore, this work provides a reliable approach for the design and preparation of silica/RE 2 O 3 nanocomposite with mesoporous hollow rod-like structures.

show abstract

Synthesis of mesoporous core-shell structured GdPO4:Eu@SiO2@mSiO2 nanorods for drug delivery and cell imaging applications

Cited by 14 publications

References 47 publications

Surface Biofunctionalization of Gadolinium Phosphate Nanobunches for Boosting Osteogenesis/Chondrogenesis Differentiation

Surface Biofunctionalization of Gadolinium Phosphate Nanobunches for Boosting Osteogenesis/Chondrogenesis Differentiation

Synthesis & PL study of GdPO4:Tb,Eu nanophosphor

Rod-shaped hollow mesoporous silica drug delivery system: synthetic design, ibuprofen delivery, and optical imaging

Contact Info

Product

Resources

About