Synthesis of mesoporous silicate molecular sieves by the aerosol-assisted method for loading and release of drug

Abstract

The mesoporous silicate molecular sieves were synthesized with polyether F127 as the template by the aerosol-assisted method for loading and release of ibuprofen (IBU). The synthesized samples were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and N 2 adsorption–desorption isotherms. The drug IBU was applied as a model drug to investigate the drug release behaviour by ultraviolet spectrophotometry measurements. The investigation results demonstrate that mesoporous silicate molecular sieves by the aerosol-assisted method are spherical with a core–shell structure. As the drug carrier, it has good structural stability and can achieve drug controlled release which is expected. It exhibits safety to a certain degree. Therefore, the aerosol-assisted synthesis method provides a new idea for the synthesis of sustained-release drug carriers.

Polymer‐based solid acid catalyst for the green production of diosgenin

“…Solid acid has been used to replace the traditional acid catalyst in some chemical processes, 12 such as conversion of biomass, 13 hydrolysis of cellulose, 14 esterification, 15 alkylation, 16 and catalytic reduction. 17 The results showed that the catalytic activity of solid acid is largely depended on acid sites on the solid surface.…”