Synthesis of methyl 1,5‐diaryl‐1H‐pyrrole‐2‐carboxylates via acid‐catalyzed ring‐opening/ring‐closure sequence

Abstract

A facile synthesis of methyl 1,5‐diaryl‐1H‐pyrrole‐2‐carboxylates was reported in this article. Acid‐catalyzed reaction of methyl 2‐aroyl‐1‐phenoxycyclopropanecarboxylates with aromatic amines underwent smoothly to give methyl 1,5‐diaryl‐1H‐pyrrole‐2‐carboxylates in high to excellent yields under mild conditions.

Construction of heterocyclic rings from cyclopropenes

“…This reaction proceeded smoothly to give the pyrrole products in high to excellent yields under mild conditions. 60 This cycloisomerization reaction has a wide substrate scope, and would be initiated by ring-opening of the protonated acylcyclopropanes (Scheme 36).…”