Synthesis of molecularly imprinted polymer by suspension polymerization for selective extraction of p‐hydroxybenzoic acid from water

Abstract

Molecularly imprinted polymer (MIP) for selective extraction of p-hydroxybenzoic acid (p-HB) was synthesized by suspension polymerization using p-HB as template, 4-vinyl pyridine as functional monomer and ethylene glycol dimethacrylate as crosslinker. As characterized by scanning electron microscopy, the MIP particles are spherical, with size ranging from 1 to 8 μm. Compared with the non-imprinted polymer (NIP), the MIP shows higher binding capacity toward p-HB: maximum binding capacity for p-HB being 8.07 μmol g −1 over MIP and 3.88 μmol g −1 over NIP. The adsorption of p-HB on MIP follows the Freundlich model and displays pseudo-second-order kinetics. The results of selective and competitive binding experiments confirm that the molecularly imprinted sites have excellent recognition ability toward p-HB. The results reveal that the MIP is a promising adsorbent for selective extraction of p-HB from water samples.

Molecularly Imprinted Polymers in Biological Applications

“…Iridoid glycosides, spiramycin, 2,4-dichlorophenoxyacetic acid, diclofenac, alfatoxins [17][18][19][20][21] Suspension polymerization Malachite green, p-hydroxybenzoic acid, timolol, alfatoxins B1, Pb 2+ [22][23][24][25][26] Emulsion polymerization Quercetin, malachite green, Listeria monocytogenes, triazines, Cd 2+ [27][28][29][30][31] Seed polymerization Nicotinamide, bisphenol A, promazine derivates [32][33][34] Precipitation polymerization Triclosan and triclocarban, strychnine, caffeic acid, vitamin E, prednisolone [35][36][37][38][39] RAFT polymerization Benzimidazole, propranolol, polycyclic aromatic hydrocarbons [40][41][42] Atom transfer radical polymerization Ofloxacin, ␤2-agonists [43,44] Sol-gel Iprodione, methylxanthines [45,46] RAFT: Reversible addition fragmentation chain transfer.…”

Solid-Phase Extraction of Active Compounds from Natural Products by Molecularly Imprinted Polymers: Synthesis and Extraction Parameters

“…As the pore sizes of the samples ranged from 2 to 50 nm, the polymers were classified as mesoporous. The morphology of MIPs that characterized by SEM via the suspension technique was discuss detailed by Liu et al [85] to synthesis MIPs for the selective extraction of 4-hydroxybenzoic acid (4-HB). It shows that the MIP particles were spherical, with sizes ranging from 1 to 8 µm, with a peak value of 5 µm, while the MIP microspheres have an average diameter of 4.8 µm.…”

Sample Preparation Using Molecularly Imprinted Polymers

“…As for MIP-SPE, MIP particles for dSPE can be obtained by bulk polymerization that gives a monolith that must be crushed and possibly sieved. 53,58,64,[143][144][145][146] More homogenous MIP microspheres can also be obtained by precipitation polymerization, 63,65,[147][148][149] suspension polymerization, 45,89 and emulsion polymerization. 150 Another option is surface imprinting, which mainly consists in dispersing a core sorbent in the polymerization solution as described in detail in recent reviews.…”

“…94 In most of the cases, 5-100 mg of particles are dispersed in the samples. The ratio between the amount of MIP particles and the volume of the sample, that has only been optimized in some cases, 68,180 can be lower than 1, 32,33,44,94,143,158,169,179 between 1 and 10, 45,50,58,59,61,64,65,89,98,106,107,111,114,117,147,154,155,[163][164][165]170,177,178,185 or up to 50 34,66,69,144,149,168,174,181,188 and even 250 mg/mL. 43 Environmental waters were filtered 172 or directly put in contact with the MIP particles for the extraction of target analytes.…”