Synthesis of Molecularly Imprinted Polymer via Visible Light Activated RAFT Polymerization in Aqueous Media at Room Temperature for Highly Selective Electrochemical Assay of Glucose

Abstract

The mild environment where most proteins and antibodies in living systems are prepared has inspired fascination among chemists. Herein, a new, rapid, low‐cost, and environment‐friendly method is proposed to synthesize molecularly imprinted polymers (MIPs) via visible light activated reversible addition–fragmentation chain transfer polymerization in aqueous media at room temperature for highly selective electrochemical assay of glucose. The MIPs with microsphere morphology, the better hydraulic distribution, large surface area, uniform large pore sizes, and high pore volume exhibit a significant adsorption efficiency compared with nonimprinted polymers for glucose. In addition, the MIP sensor recognizing the glucose significantly exceeds that of the other saccharide analogs, possesses regenerative ability, and presents high sensitivity by applying for the detection of glucose in human urine samples.

Molecularly imprinted polymersviareversible addition–fragmentation chain-transfer synthesis in sensing and environmental applications

“… 77 Once this reaction design is made to achieve a specific molecular architecture and terminal functional group via a specific RAFT chain-transfer equilibrium, the resulting polymer needs to be evaluated so the efficiency and accuracy of the tailor made material are evaluated. 125 It is important to evaluate the following properties because they are expected to be improved since RAFT was added in the reaction design despite the characterization technique is the same for both free radical and controlled radical polymerizations.…”

Recent Applications of Point-of-Care Devices for Glucose Detection on the Basis of Stimuli-Responsive Volume Phase Transition of Hydrogel

“…b The detection of glucose and its ana-logs in maximum equilibrium concentration at ambient temperature (reprinted with permission from Ref. [93]) less increment in osmotic pressure and resulting in shrinking [8]. For the latter, the binding of PBA to glucose in 1:1 promotes the formation of boronate anion, increasing the mixing free energy and osmotic pressure due to the increased hydrophilic species in hydrogel network, thus swelling [65].…”

“…and tear including structure color [74,87,[125][126][127], etc., there are many studies suitable for blood including structure color [115,126], fluorescence [39,40,104], electrical [109], etc. and urine including structure color [128,129], electrical [93] etc. as well.…”

Preparation of P(EGDMA‐co‐VPBA) Adsorbent and Its Application in the Separation of Steviol Glycosides

“…[6] In recent years, with the development of adsorption materials, the adsorption method has been regarded as a high efficiency separation method. [7] The adsorption materials commonly used in current research involve MOFs, [8] silica-based materials, [9,10] carbon-based materials, [11,12] magnetic composite [13][14][15] and macroporous adsorption resin (MAR), COFs, [16,17] molecularly imprinted polymers (MIPs), [18][19][20][21][22][23][24] and other organic polymers. [25][26][27][28][29] Organic polymer adsorbents have become universal adsorbent materials with varieties of attractive merits, for example adjustable monomer components, relatively low-cost, structure diversity, and facile functionalization.…”