Synthesis of monosubstituted calix[4]pyrroles in β position

Abstract

Through lithiation and electrophilic substitution of three calix [4]pyrroles, a series of new calix[4]pyrrole derivatives were synthesised. The derivatives were hydrolysed to produce acids and, under base catalysis, new esters were formed. Thus calix [4]pyrroles with an active functional group were obtained. The optimum reaction and purification conditions were investigated. The binding properties of the new derivatives with anions was examined.

Synthesis of New Trisulfonated Calix[4]arenes Functionalized at the Upper Rim, and Their Complexation with the Trimethyllysine Epigenetic Mark

“…Despite the dominant position of sulfonated calixarenes among water-soluble supramolecular hosts, we found that examples bearing modifications on the upper rim such as the monosubstituted, trisulfonated calix[4]arenes exemplified by 2 (Figure ) have not been prepared synthetically or explored as supramolecular hosts. Recent work has highlighted the importance of selective functionalization of a variety of other macrocylic systems, such as calixpyrroles and cyclodextrins, in the tuning of binding properties and development of new technologies. , …”