Synthesis of multi-functional nanocapsules via interfacial AGET ATRP in miniemulsion for tumor micro-environment responsive drug delivery

Tian, Kun; Zeng, Jin; Zhao, Xubo; Liu, Lei; Jia, Xu; Liu, Peng

doi:10.1016/j.colsurfb.2015.06.057

Cited by 24 publications

(18 citation statements)

References 33 publications

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“…Subsequently, the monomer was added along with cross-linker and initiator and started to form polymeric shell via free radical polymerization. Then the pre-synthesized amphiphilic copolymer was removed by hydrolysis to provide hollow inner structure [102][103][104]. For example, pH sensitive polymeric nanocapsules were formulated by using RAFT/emulsion polymerization.…”

Section: B Emulsion-coacervation Methodsmentioning

confidence: 99%

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell. This is of increasing interest in drug delivery applications. In this review, nanocapsules delivery systems studied in last decade are reviewed, along with nanocapsule formulation, characterizations of physical/chemical/biologic properties and applications. Furthermore, the challenges and opportunities of nanocapsules applications are also proposed.

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Section: B Emulsion-coacervation Methodsmentioning

confidence: 99%

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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“…To investigate the drug loading properties of crosslinked micelles, DOX was used as a model drug molecule because the p K a of DOX is 8.25 and it is a positively charged cation in neutral and acidic environments . It can be loaded into the electronegative crosslinked micelles by electrostatic interaction at neutral pH …”

Section: Resultsmentioning

confidence: 99%

Temperature, pH, and reduction triple‐stimuli‐responsive inner‐layer crosslinked micelles as nanocarriers for controlled release

Zhang

Liu

et al. 2018

J of Applied Polymer Sci

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Temperature, pH, and reduction triple‐stimuli‐responsive inner‐layer crosslinked micelles as nanocarriers for drug delivery and release are designed. The well‐defined tetrablock copolymer poly(polyethylene glycol methacrylate)–poly[2‐(dimethylamino) ethyl methacrylate]–poly(N‐isopropylacrylamide)–poly(methylacrylic acid) (PPEGMA‐PDMAEMA‐PNIPAM‐PMAA) is synthesized via atom transfer radical polymerization, click chemistry, and esterolysis reaction. The tetrablock copolymer self‐assembles into noncrosslinked micelles in acidic aqueous solution. The core‐crosslinked micelles, shell‐crosslinked micelles, and shell–core dilayer‐crosslinked micelles are prepared via quaternization reaction or carbodiimide chemistry reaction. The crosslinked micelles are used as drug carriers to load doxorubicin (DOX), and the drug encapsulation efficiency with 20% feed ratio reached 59.2%, 73.1%, and 86.1%, respectively. The cumulative release rate of DOX is accelerated by single or combined stimulations. The MTT (3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) assay verifies that the inner‐layer crosslinked micelles show excellent cytocompatibility, and DOX‐loaded micelles exhibit significantly higher inhibition for HepG2 cell proliferation. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46714.

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“…On the other hand, crosslinker can also be utilized to introduce stimuli‐responsivity to the resulting CPNCs. For instance, Tian et al synthesized pH and reduction dual‐responsive PEG‐ block ‐poly(acrylic acid)‐based CPNCs in which pH‐sensitivity was from polymeric structures and reduction responsivity was from the disulfide‐functionalized crosslinker, N , N ‐bis(acryloyl) cystamine (Tian et al, 2015). Drug release from these CPNCs became fast at pH 5.0 relative to pH 7.4, and could be critically triggered with the presence of glutathione (GSH) as the reducing agent to cleave the disulfide‐based crosslinkages of the CPNCs.…”

Section: Therapeutic Applications Of Cpncsmentioning

confidence: 99%

Crosslinked polymer nanocapsules for therapeutic, diagnostic, and theranostic applications

Sun

Erdman

Yuan

et al. 2020

WIREs Nanomed Nanobiotechnol

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Crosslinked polymer nanocapsules (CPNCs) are hollowed nanoparticles with network-like polymeric shells stabilized by primary bonds. CPNCs have drawn broad and significant interests as nanocarriers for biomedical applications in recent years. As compared with conventional polymeric nanoparticles systems without cavity and/or crosslinking architectures, CPNCs possess significant biomedical relevant advantages, including (a) superior structural stability against environmental conditions, (b) high loading capacity and ability for region-specific loading of multiple cargos, (c) tuneable cargo release rate via crosslinking density, and (d) high specific surface area to facilitate surface adsorption, modification, and interactions. With appropriate base polymers and crosslinkages, CPNCs can be biocompatible and biodegradable. While CPNCbased biomedical nanoplatforms can possess relatively stable physicochemical properties owing to their crosslinked architectures, various biomedically relevant stimuli-responsivities can be incorporated with them through specific structural designs. CPNCs have been studied for the delivery of small molecule drugs, genes, proteins, and other therapeutic agents. They have also been investigated as diagnostic platforms for magnetic resonance imaging, ultrasound imaging, and optical imaging. Moreover, CPNCs have been utilized to carry both therapeutics and bioimaging agents for theranostic applications. This article reviews the therapeutic, diagnostic and theranostic applications of CPNCs, as well as the preparation of these CPNCs, reported in the past decade.

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Synthesis of multi-functional nanocapsules via interfacial AGET ATRP in miniemulsion for tumor micro-environment responsive drug delivery

Cited by 24 publications

References 33 publications

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Temperature, pH, and reduction triple‐stimuli‐responsive inner‐layer crosslinked micelles as nanocarriers for controlled release

Crosslinked polymer nanocapsules for therapeutic, diagnostic, and theranostic applications

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